Delta-Like Ligand 4-Notch Signaling in Macrophage Activation

被引：62

作者：

Nakano, Toshiaki ^{[1
,3
]}

Fukuda, Daiju ^{[1
,3
]}

Koga, Jun-ichiro ^{[1
,3
]}

Aikawa, Masanori ^{[1
,2
,3
,4
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, Boston, MA 02115 USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA

[4] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA 02115 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2016年 / 36卷 / 10期

基金：

美国国家卫生研究院; 日本学术振兴会;

关键词：

atherosclerosis; fatty liver; inflammation; macrophage; metabolic disease; veins; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; VEIN GRAFT FAILURE; ADIPOSE-TISSUE; OSTEOGENIC DIFFERENTIATION; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; IMMUNE-SYSTEM;

D O I：

10.1161/ATVBAHA.116.306926

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Notch signaling pathway regulates the development of various cell types and organs, and also contributes to disease mechanisms in adults. Accumulating evidence suggests its role in cardiovascular and metabolic diseases. Notch signaling components also control the phenotype of immune cells. Delta-like ligand 4 (Dll4) of the Notch pathway promotes proinflammatory activation of macrophages in vitro and in vivo. Dll4 blockade attenuates chronic atherosclerosis, vein graft disease, vascular calcification, insulin resistance, and fatty liver in mice. The Dll4-Notch axis may, thus, participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.

引用

收藏

页码：2038 / 2047

页数：10

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