Correction of metabolic processes in rats during chronic endotoxicosis using isotope (D/H) exchange reactions

被引：16

作者：

Dzhimak, S. S. ^{[1
]}

Basov, A. A. ^{[2
]}

Fedulova, L. V. ^{[3
]}

Didikin, A. S. ^{[3
]}

Bikov, I. M. ^{[2
]}

Arcybasheva, O. M. ^{[1
]}

Naumov, G. N. ^{[4
]}

Baryshev, M. G. ^{[1
]}

机构：

[1] Kuban State Univ, Krasnodar 350040, Russia

[2] Kuban State Med Univ, Minist Hlth, Krasnodar 350063, Russia

[3] Gorbatov All Russia Res Inst Meat Ind, Moscow 109316, Russia

[4] Krasnodar Municipal Med Inst Higher Nursing Educ, Krasnodar 350000, Russia

来源：

BIOLOGY BULLETIN | 2015年 / 42卷 / 05期

关键词：

OXIDATIVE STRESS; EXPERIMENTAL-ANIMALS; DEUTERIUM; OXYGEN; GROWTH; WATER;

D O I：

10.1134/S1062359015050064

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of isotope exchange reactions (deuterium/protium, D/H) on morphofunctional indices and the state of the antioxidant blood system in rats was studied under physiological conditions and during experimental chronic endotoxicosis of hepatorenal genesis. It was demonstrated that introduction of water with a decreased content of deuterium in the food rations of rats results in a decrease in its concentration in the blood plasma by 32-36% (to 98-106 ppm) and in lyophilized liver, kidney, and heart tissues by 13-17% (to 123-128 ppm). It was noted that it is accompanied by correction of metabolic processes, an increase in the functional activity of nonspecific protection system, and an increase in the body weight growth by the 42nd day in the group of animals that passed (for 14 days) the stage of preliminary adaptation with a change in the D/H ratio in the organism.

引用

页码：440 / 448

页数：9

共 35 条

[1]

[Anonymous], 2006, OKISLITELNYI STRESS

[2] NMR, EPR, and mass spectroscopy estimates of the antiradical activity of water with modified isotope composition [J].

Baryshev, M.G. ;

Basov, A.A. ;

Bolotin, S.N. ;

Dzhimak, S.S. ;

Kashaev, D.V. ;

Fedosov, S.R. ;

Frolov, V. Yu ;

Shashkov, D.I. ;

Lysak, D.A. ;

Timakov, A.A. .

Bulletin of the Russian Academy of Sciences: Physics, 2012, 76 (12) :1349-1352

[3]

Baryshev M. G., 2010, NAUKA KUBANI, P18

[4]

Baryshev M.G., 2013, ECOLOGICAL B RES CTR, P13

[5]

Basov A. A., 2014, Voprosy Pitaniya, V83, P43

[6]

Basov A. A., 2013, Voprosy Pitaniya, V82, P75

[7]

Basov A. A., 2006, SOVREM PROBL NAUKI O, P149

[8]

BOLDYREV AA, 2001, SOROS OBRAZ ZH, V7, P21

[9]

Brodskii A. I., 1957, KHIMIYA IZOTOPOV

[10] Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: Mitochondrial targeted preconditioning [J].

Busija, David W. ;

Gaspar, Tamas ;

Domoki, Ferenc ;

Katakam, Prasad V. ;

Bari, Ferenc .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (13-14) :1471-1477

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