Evaluation of European tick-borne encephalitis virus vaccine against recent Siberian and far-eastern subtype strains

被引：30

作者：

Hayasaka, D ^{[1
]}

Goto, A ^{[1
]}

Yoshii, K ^{[1
]}

Mizutani, T ^{[1
]}

Kariwa, H ^{[1
]}

Takashima, I ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Environm Vet Sci, Publ Hlth Lab, Sapporo, Hokkaido 0600818, Japan

来源：

VACCINE | 2001年 / 19卷 / 32期

基金：

日本学术振兴会;

关键词：

Siberian and far-eastern Russia; TBE; vaccine;

D O I：

10.1016/S0264-410X(01)00218-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the efficacy of the European TBE, vaccine in east-Siberian and far-eastern. regions of Russia, we examined the immune responses of the vaccine against recent TBE virus Siberian (Irkutsk) and far-eastern (Khabarovsk and Vladivostok) isolates. The sera of vaccinated humans showed efficient neutralizing antibody titers (greater than or equal to 20) against Siberian and far-eastern strains. To evaluate the efficacy of the vaccine in vivo, mice were vaccinated and challenged with lethal doses of the viruses. All vaccinated mice survived each virus challenge. These-results suggest that the European vaccine can prevent the TBE virus infection in east-Siberian and far-eastern regions of Russia. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：4774 / 4779

页数：6

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