Colorectal cancer vaccines in clinical trials

被引：1

作者：

Speetjens, Frank M. ^{[1
]}

Zeestraten, Eliane C. M. ^{[1
]}

Kuppen, Peter J. K. ^{[1
]}

Melief, Cornelis J. M. ^{[2
]}

van der Burg, Sjoerd H. ^{[1
]}

机构：

[1] Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands

[2] ISA Pharmaceut BV, Leiden, Netherlands

来源：

EXPERT REVIEW OF VACCINES | 2011年 / 10卷 / 06期

关键词：

cancer; colon; colorectal; immune monitoring; immunotherapy; therapeutic; vaccine; ACTIVE SPECIFIC IMMUNOTHERAPY; T-CELL RESPONSES; FRAMESHIFT-INDUCED NEOPEPTIDES; P53-SPECIFIC IMMUNE-RESPONSES; LONG PEPTIDE VACCINE; HUMAN TUMOR-ANTIGENS; MEDIAN FOLLOW-UP; PHASE-I TRIAL; CARCINOEMBRYONIC ANTIGEN; DENDRITIC CELLS;

D O I：

10.1586/ERV.11.63

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article elucidates current strategies of active immunotherapy for colorectal cancer patients with a focus on T-cell mediated immunotherapy. Poor prognosis of especially stage III and IV colorectal cancer patients emphasizes the need for advanced therapeutic intervention. Here, we refer to clinical trials using either tumor cell-derived vaccines or tumor antigen vaccines with a special interest on safety, induced immune responses, clinical benefit and efforts to improve the clinical impact of these vaccines in the context of colorectal cancer treatment.

引用

页码：899 / 921

页数：23

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