Cardiac Sarcoidosis: Current Approaches to Diagnosis and Management

被引:5
作者
Rosario, Karen Flores [1 ]
Brezitski, Kyla [1 ]
Arps, Kelly [1 ]
Milne, Megan [2 ]
Doss, Jayanth [2 ]
Karra, Ravi [1 ,3 ]
机构
[1] Duke Univ, Dept Med, Div Cardiol, Med Ctr, Durham, NC 27710 USA
[2] Duke Univ, Dept Med, Div Rheumatol, Med Ctr, Durham, NC 27710 USA
[3] Duke Univ, Dept Pathol, Med Ctr, Box 102152 DUMC, Durham, NC 27710 USA
关键词
Cardiac sarcoidosis; Non-caseating granulomas; Biomarkers; Immunosuppression; CORTICOSTEROID-THERAPY; GRANULOMA-FORMATION; JAPANESE PATIENTS; HIV-INFECTION; TNF-ALPHA; HEART; IMPACT; CELLS; EPIDEMIOLOGY; INITIATION;
D O I
10.1007/s11882-022-01046-x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of Review Cardiac sarcoidosis (CS) is an important cause of non-ischemic cardiomyopathy and has specific diagnostic and therapeutic considerations. With advances in imaging techniques and treatment approaches, the approach to monitoring disease progression and management of CS continues to evolve. The purpose of this review is to highlight advances in CS diagnosis and treatment and present a center's multidisciplinary approach to CS care. Recent Findings In this review, we highlight advances in granuloma biology along with contemporary diagnostic approaches. Moreover, we expand on current targets of immunosuppression focused on granuloma biology and concurrent advances in the cardiovascular care of CS in light of recent guideline recommendations. Summary Here, we review advances in the understanding of the sarcoidosis granuloma along with contemporary diagnostic and therapeutic considerations for CS. Additionally, we highlight knowledge gaps and areas for future research in CS treatment.
引用
收藏
页码:171 / 182
页数:12
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