Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: Role in neurodegenerative diseases

被引：153
作者：
Burke, WJ [1 ]
Li, SW
Chung, HD
Ruggiero, DA
Kristal, BS
Johnson, EM
Lampe, P
Kumar, VB
Franko, M
Williams, EA
Zahm, DS
机构：
[1] St Louis Univ, Hlth Sci Ctr, Vet Affairs Med Ctr, Dept Neurol, St Louis, MO 63110 USA
[2] Columbia Univ Coll Phys & Surg, Dept Anat Cell Biol & Psychiat, New York, NY 10032 USA
[3] Burke Med Res Inst, Dementia Res Serv, White Plains, NY 10605 USA
[4] Cornell Univ, Weill Med Coll, Dept Biochem & Neurosci, New York, NY 10021 USA
[5] Washington Univ, Sch Med, Dept Pharmacol, St Louis, MO 63110 USA
[6] St Louis Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63104 USA
[7] St Louis Univ, Hlth Sci Ctr, Vet Affairs Med Ctr, Dept Pathol, St Louis, MO 63110 USA
[8] St Louis Univ, Hlth Sci Ctr, Vet Affairs Med Ctr, Dept Med, St Louis, MO 63110 USA
来源：
NEUROTOXICOLOGY | 2004年 / 25卷 / 1-2期
关键词：
3,4-dihydroxyphenylglycolaldehyde; 3,4-dihydroxyphenylacetaldehyde; MAO; catecholamine metabolites; Alzheimer's disease; Parkinson's disease;
D O I：
10.1016/S0161-813X(03)00090-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The monoamine oxidase (MAO) metabolites of norepinephrine (NE) or epinephrine (EPI) and of dopamine (DA) are 3,4-dihydroxyphenyglycolaldehye (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively. The toxicity of these catecholamine (CA) MAO metabolites was predicted over 50 years ago. However, until our recent chemical synthesis of these CA aldehyde metabolites, the hypothesis about their toxicity could not be tested. The present paper reviews recent knowledge gained about these compounds. Topics to be reviewed include: chemical synthesis and properties of DOPEGAL and DOPAL; in vitro and in vivo toxicity of CA aldehydes; subcellular mechanisms of toxicity; free radical formation by DOPEGAL versus DOPAL; mechanisms of accumulation of CA aldehydes in Alzheimer's disease (AD) and Parkinson's disease (PD) and potential therapeutic targets in Alzheimer's disease and Parkinson's disease. (C) 2003 Published by Elsevier Inc.
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收藏
页码：101 / 115
页数：15
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