Telaprevir User's Guide

被引：10

作者：

Liapakis, AnnMarie ^{[1
]}

Jacobson, Ira ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Div Gastroenterol & Hepatol, New York, NY 10021 USA

来源：

CLINICS IN LIVER DISEASE | 2011年 / 15卷 / 03期

关键词：

Telaprevir; Hepatitis C virus; User's guide; Interferon; Ribavirin; Protease inhibitor; HEPATITIS-C VIRUS; PEGINTERFERON; RIBAVIRIN; REPLICATION; MANAGEMENT; VX-950;

D O I：

10.1016/j.cld.2011.05.013

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

For a decade, standard therapy for patients with genotype 1 chronic HCV (HCV G1) consisted of pegylated interferon (Peg-IFN) alfa-2a or Peg-IFN alfa-2b, combined with ribavirin. Despite the improved efficacy of this therapy over others, the overall sustained virologic response rate in patients with HCV G1 was still low. This article discusses phase I, II, and III trials examining telaprevir's role in treating patients with HCV. We have now entered an era of combination therapy utilizing direct acting anti-virals, the start of which was marked by the FDA approval of HCV protease inhibitors.

引用

页码：555 / +

页数：18

共 23 条

[1]

[Anonymous], TEL INCIVEK PACK INS

[2] American Gastroenterological Association technical review on the management of hepatitis C [J].

Dienstag, JL ;

McHutchison, JG .

GASTROENTEROLOGY, 2006, 130 (01) :231-264

[3] Rising incidence of hepatocellular carcinoma in the United States [J].

El-Serag, HB ;

Mason, AC .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (10) :745-750

[4] Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C [J].

Forestier, Nicole ;

Reesink, Hendrik W. ;

Weegink, Christine J. ;

McNair, Lindsay ;

Kieffer, Tara L. ;

Chu, Hui-May ;

Purdy, Susan ;

Jansen, Peter L. M. ;

Zeuzem, Stefan .

HEPATOLOGY, 2007, 46 (03) :640-648

[5] SUBANALYSES OF THE TELAPREVIR LEAD-IN ARM IN THE REALIZE STUDY: RESPONSE AT WEEK 4 IS NOT A SUBSTITUTE FOR PRIOR NULL RESPONSE CATEGORIZATION [J].

Foster, G. R. ;

Zeuzem, S. ;

Andreone, P. ;

Pol, S. ;

Lawitz, E. J. ;

Diago, M. ;

Roberts, S. ;

Pockros, P. J. ;

Younossi, Z. ;

Lonjon-Domanec, I. ;

Van Heeswijk, R. ;

de Meyer, S. ;

Luo, D. ;

George, S. ;

Beumont, M. ;

Picchio, G. .

JOURNAL OF HEPATOLOGY, 2011, 54 :S3-S4

[6] Diagnosis, Management, and Treatment of Hepatitis C: An Update [J].

Ghany, Marc G. ;

Strader, Doris B. ;

Thomas, David L. ;

Seeff, Leonard B. .

HEPATOLOGY, 2009, 49 (04) :1335-1374

[7] Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection [J].

Hezode, Christophe ;

Forestier, Nicole ;

Dusheiko, Geoffrey ;

Ferenci, Peter ;

Pol, Stanislas ;

Goeser, Tobias ;

Bronowicki, Jean-Pierre ;

Bourliere, Marc ;

Gharakhanian, Shahin ;

Bengtsson, Leif ;

McNair, Lindsay ;

George, Shelley ;

Kieffer, Tara ;

Kwong, Ann ;

Kauffman, Robert S. ;

Alam, John ;

Pawlotsky, Jean-Michel ;

Zeuzem, Stefan .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (18) :1839-1850

[8] Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection [J].

Jacobson, Ira M. ;

McHutchison, John G. ;

Dusheiko, Geoffrey ;

Di Bisceglie, Adrian M. ;

Reddy, K. Rajender ;

Bzowej, Natalie H. ;

Marcellin, Patrick ;

Muir, Andrew J. ;

Ferenci, Peter ;

Flisiak, Robert ;

George, Jacob ;

Rizzetto, Mario ;

Shouval, Daniel ;

Sola, Ricard ;

Terg, Ruben A. ;

Yoshida, Eric M. ;

Adda, Nathalie ;

Bengtsson, Leif ;

Sankoh, Abdul J. ;

Kieffer, Tara L. ;

George, Shelley ;

Kauffman, Robert S. ;

Zeuzem, Stefan .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (25) :2405-2416

[9] Treatment Options for Patients With Chronic Hepatitis C Not Responding to Initial Antiviral Therapy [J].

Jacobson, Ira M. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2009, 7 (09) :921-930

[10]

Kieffer T, 2010, 61 ANN M AM ASS STUD

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