X-change symposium: status and future of modern radiation oncology-from technology to biology

被引：2

作者：

Corradini, Stefanie ^{[1
]}

Niyazi, Maximilian ^{[1
]}

Verellen, Dirk ^{[2
]}

Valentini, Vincenzo ^{[3
]}

Walsh, Sean ^{[4
]}

Grosu, Anca-L. ^{[5
,6
]}

Lauber, Kirsten ^{[1
]}

Giaccia, Amato ^{[7
]}

Unger, Kristian ^{[8
]}

Debus, Juergen ^{[9
]}

Pieters, Bradley R. ^{[10
]}

Guckenberger, Matthias ^{[11
]}

Senan, Suresh ^{[12
]}

Budach, Wilfried ^{[13
]}

Rad, Roland ^{[14
]}

Mayerle, Julia ^{[15
]}

Belka, Claus ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiat Oncol, Marchioninistr 15, D-81377 Munich, Germany

[2] Univ Antwerp, Dept Radiotherapy, Iridium Network, Fac Med & Hlth Sci, Antwerp, Belgium

[3] Univ Cattolica S Cuore, Dept Radiat Oncol & Hematol, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[4] Oncoradiomics, Liege, Belgium

[5] Univ Freiburg, Fac Med, Dept Radiat Oncol, Med Ctr, Freiburg, Germany

[6] German Canc Consortium DKTK, Partner Site Freiburg, Freiburg, Germany

[7] Stanford Univ, Div Radiat & Canc Biol, Dept Radiat Oncol, Stanford, CA USA

[8] Helmholtz Zentrum Munich, Integrat Biol Grp, Munich, Germany

[9] Heidelberg Univ Hosp, Dept Radiat Oncol, Heidelberg, Germany

[10] Univ Amsterdam, Med Ctr, Locat Acad Med Ctr, Dept Radiat Oncol, Amsterdam, Netherlands

[11] Univ Zurich, Univ Hosp Zurich, Dept Radiat Oncol, Zurich, Switzerland

[12] Univ Amsterdam, Dept Radiat Oncol, Med Ctr, Amsterdam, Netherlands

[13] Heinrich Heine Univ, Fac Med, Dept Radiat Oncol, Dusseldorf, Germany

[14] Tech Univ Munich, Ctr Translat Canc Res TranslaTUM, Munich, Germany

[15] LMU, Univ Hosp, Dept Internal Med 2, Munich, Germany

来源：

RADIATION ONCOLOGY | 2021年 / 16卷 / 01期

关键词：

EXTERNAL-BEAM RADIOTHERAPY; RATE BRACHYTHERAPY BOOST; LOCALLY ADVANCED HEAD; HIGH-DOSE-RATE; PROSTATE-CANCER; CERVICAL-CANCER; PROTON THERAPY; NECK-CANCER; RANDOMIZED-TRIAL; UVEAL MELANOMA;

D O I：

10.1186/s13014-021-01758-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Future radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices in modern image-guided radiotherapy; the emerging field of radiomics; the role of molecular imaging using positron emission tomography and its integration into clinical routine; radiation biology with its future perspectives, the role of molecular signatures in prognostic modelling; as well as special treatment modalities such as brachytherapy or proton beam therapy are areas of rapid development. More clinically, radiation oncology will certainly find an important role in the management of oligometastasis. The treatment spectrum will also be widened by the rational integration of modern systemic targeted or immune therapies into multimodal treatment strategies. All these developments will require a concise rethinking of clinical trial design. This article reviews the current status and the potential developments in the field of radiation oncology as discussed by a panel of European and international experts sharing their vision during the "X-Change" symposium, held in July 2019 in Munich (Germany).

引用

页数：17

共 158 条

[1] The FLASH effect depends on oxygen concentration [J].

Adrian, Gabriel ;

Konradsson, Elise ;

Lempart, Michael ;

Back, Sven ;

Ceberg, Crister ;

Petersson, Kristoffer .

BRITISH JOURNAL OF RADIOLOGY, 2020, 93 (1106)

[2] Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach [J].

Aerts, Hugo J. W. L. ;

Velazquez, Emmanuel Rios ;

Leijenaar, Ralph T. H. ;

Parmar, Chintan ;

Grossmann, Patrick ;

Cavalho, Sara ;

Bussink, Johan ;

Monshouwer, Rene ;

Haibe-Kains, Benjamin ;

Rietveld, Derek ;

Hoebers, Frank ;

Rietbergen, Michelle M. ;

Leemans, C. Rene ;

Dekker, Andre ;

Quackenbush, John ;

Gillies, Robert J. ;

Lambin, Philippe .

NATURE COMMUNICATIONS, 2014, 5

[3] Reprogramming the immunological microenvironment through radiation and targeting Axl [J].

Aguilera, Todd A. ;

Rafat, Marjan ;

Castellini, Laura ;

Shehade, Hussein ;

Kariolis, Mihalis S. ;

Hui, Angela Bik-Yu ;

Stehr, Henning ;

von Eyben, Rie ;

Jiang, Dadi ;

Ellies, Lesley G. ;

Koong, Albert C. ;

Diehn, Maximilian ;

Rankin, Erinn B. ;

Graves, Edward E. ;

Giaccia, Amato J. .

NATURE COMMUNICATIONS, 2016, 7

[4]

[Anonymous], Economist

[5] Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC [J].

Antonia, S. J. ;

Villegas, A. ;

Daniel, D. ;

Vicente, D. ;

Murakami, S. ;

Hui, R. ;

Kurata, T. ;

Chiappori, A. ;

Lee, K. H. ;

de Wit, M. ;

Cho, B. C. ;

Bourhaba, M. ;

Quantin, X. ;

Tokito, T. ;

Mekhail, T. ;

Planchard, D. ;

Kim, Y. -C. ;

Karapetis, C. S. ;

Hiret, S. ;

Ostoros, G. ;

Kubota, K. ;

Gray, J. E. ;

Paz-Ares, L. ;

Carpeno, J. de Castro ;

Faivre-Finn, C. ;

Reck, M. ;

Vansteenkiste, J. ;

Spigel, D. R. ;

Wadsworth, C. ;

Melillo, G. ;

Taboada, M. ;

Dennis, P. A. ;

Ozguroglu, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (24) :2342-2350

[6] End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography [J].

Ardila, Diego ;

Kiraly, Atilla P. ;

Bharadwaj, Sujeeth ;

Choi, Bokyung ;

Reicher, Joshua J. ;

Peng, Lily ;

Tse, Daniel ;

Etemadi, Mozziyar ;

Ye, Wenxing ;

Corrado, Greg ;

Naidich, David P. ;

Shetty, Shravya .

NATURE MEDICINE, 2019, 25 (06) :954-+

[7] Comparison of organ-at-risk sparing and plan robustness for spot-scanning proton therapy and volumetric modulated arc photon therapy in head-and-neck cancer [J].

Barten, Danique L. J. ;

Tol, Jim P. ;

Dahele, Max ;

Slotman, Ben J. ;

Verbakel, Wilko F. A. R. .

MEDICAL PHYSICS, 2015, 42 (11) :6589-6598

[8] High Expression of EpCAM and Sox2 is a Positive Prognosticator of Clinical Outcome for Head and Neck Carcinoma [J].

Baumeister, Philipp ;

Hollmann, Alessandra ;

Kitz, Julia ;

Afthonidou, Artemis ;

Simon, Florian ;

Shakhtour, Julius ;

Mack, Brigitte ;

Kranz, Gisela ;

Libl, Darko ;

Leu, Martin ;

Schirmer, Markus A. ;

Canis, Martin ;

Belka, Claus ;

Zitzelsberger, Horst ;

Ganswindt, Ute ;

Hess, Julia ;

Jakob, Mark ;

Unger, Kristian ;

Gires, Olivier .

SCIENTIFIC REPORTS, 2018, 8

[9]

Bera Kaustav, 2018, Am Soc Clin Oncol Educ Book, V38, P1008, DOI 10.1200/EDBK_199747

[10] SUMO pathway inhibition targets an aggressive pancreatic cancer subtype [J].

Biederstadt, Alexander ;

Hassan, Zonera ;

Schneeweis, Christian ;

Schick, Markus ;

Schneider, Lara ;

Muckenhuber, Alexander ;

Hong, Yingfen ;

Siegers, Gerrit ;

Nilsson, Lisa ;

Wirth, Matthias ;

Dantes, Zahra ;

Steiger, Katja ;

Schunck, Kathrin ;

Langston, Steve ;

Lenhof, H-P ;

Coluccio, Andrea ;

Orben, Felix ;

Slawska, Jolanta ;

Scherger, Anna ;

Saur, Dieter ;

Mueller, Stefan ;

Rad, Roland ;

Weichert, Wilko ;

Nilsson, Jonas ;

Reichert, Maximilian ;

Schneider, Gueter ;

Keller, Ulrich .

GUT, 2020, 69 (08) :1472-1482

← 1 2 3 4 5 6 7 8 9 10 →