Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa

被引：4
作者：
Sanchis, Marta [1 ]
Sutton, Deanna A. [2 ]
Wiederhold, Nathan P. [2 ]
Guarro, Josep [1 ]
Capilla, Javier [1 ]
机构：
[1] Univ Rovira & Virgili, IISPV, Unitat Microbiol, Fac Med & Ciencies Salut, Tarragona, Spain
[2] Univ Texas Hlth Sci Ctr San Antonio, Fungus Testing Lab, San Antonio, TX 78229 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 86卷 / 01期
关键词：
Anidulafungin; Caspofungin; Diutina rugosa; Antifungals; Fungal infections; Animal model; AMPHOTERICIN-B; TIME-KILL; SPECIES COMPLEX; CASPOFUNGIN; ANIDULAFUNGIN; MICAFUNGIN; GUILLIERMONDII; PARAPSILOSIS; VORICONAZOLE; NEORUGOSA;
D O I：
10.1016/j.diagmicrobio.2016.05.014
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：61 / 65
页数：5
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