Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

被引：78

作者：

Vinken, Mathieu ^{[1
]}

机构：

[1] Vrije Univ Brussel, Dept In Vitro Toxicol & Dermatocosmetol, Brussels, Belgium

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2015年 / 28卷 / 07期

基金：

巴西圣保罗研究基金会; 欧洲研究理事会;

关键词：

SALT EXPORT PUMP; HEPATIC-FIBROSIS; RAT HEPATOCYTES; RISK-ASSESSMENT; MECHANISMS; TOXICITY; CHOLESTASIS; INSIGHTS; HEPATOTOXICITY; BIOMARKERS;

D O I：

10.1021/acs.chemrestox.5b00208

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Drug-induced liver injury is a prominent reason for premarketing and postmarketing drug withdrawal and can be manifested in a number of ways, such as cholestasis, steatosis, and fibrosis. The mechanisms driving these toxicological processes have been well characterized and have been emdedded in adverse outcome pathway frameworks in recent years. This review evaluates these constructs and simultaneously illustrates their use in the preclinical testing of drug-induced liver injury.

引用

页码：1391 / 1397

页数：7

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