Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder

被引：251

作者：

Stroehle, Andreas ^{[1
]}

Stoy, Meline ^{[1
]}

Wrase, Jana ^{[1
]}

Schwarzer, Steffi ^{[1
]}

Schlagenhauf, Florian ^{[1
]}

Huss, Michael ^{[2
]}

Hein, Jakob ^{[1
]}

Nedderhut, Anke ^{[1
]}

Neumann, Britta ^{[1
]}

Gregor, Andreas ^{[1
]}

Juckel, Georg ^{[1
]}

Knutson, Brian ^{[3
]}

Lehmkuhl, Ulrike ^{[2
]}

Bauer, Michael ^{[1
]}

Heinz, Andreas ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Child & Adolescent Psychiat & Psychotherapy, Campus Virchow Klinikum, Berlin, Germany

[3] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

来源：

NEUROIMAGE | 2008年 / 39卷 / 03期

关键词：

attention-deficit/hyperactivity disorder; reward; anticipation; outcome; fMRI; striatum; orbitofrontal cortex;

D O I：

10.1016/j.neuroimage.2007.09.044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Attention-deficit/hyperactivity disorder (ADHD) has been suggested to involve deficits in reward processing. We used functional magnetic resonance imaging (fMRI) to compare the neural responses to reward anticipation and outcomes in 10 adults with ADHD and 10 controls as they played a monetary incentive delay task. Adults with ADHD were unmediated, and groups were matched for age, verbal IQ and smoking habits. Adults with ADHD showed decreased activation in the ventral striatum during the anticipation of gain, but increased activation of the orbitofrontal cortex in response to gain outcomes. Ventral striatal activation in adults with ADHD during gain anticipation was negatively correlated with self-rated symptoms of hyperactivity and impulsivity. These findings suggest that mate adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：966 / 972

页数：7

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