Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

被引：127

作者：

Li, Jie ^{[1
,2
,3
,4
]}

Zhao, Jiaqian ^{[2
,3
,4
,5
]}

Tan, Tiantian ^{[2
,3
,4
]}

Liu, Mengmeng ^{[2
,3
,4
]}

Zeng, Zhaowu ^{[2
,3
,4
]}

Zeng, Yiying ^{[2
,3
,4
]}

Zhang, Lele ^{[6
]}

Fu, Chaomei ^{[1
]}

Chen, Dajing ^{[2
,3
,4
]}

Xie, Tian ^{[2
,3
,4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu, Sichuan, Peoples R China

[2] Hangzhou Normal Univ, Holist Integrat Pharm Inst, 1378 Wenyixi Rd, Hangzhou 311121, Zhejiang, Peoples R China

[3] Key Lab Elemene Class Anticanc Chinese Med Zhejia, Hangzhou, Zhejiang, Peoples R China

[4] Engn Lab Dev & Applicat Tradit Chinese Med Zhejie, Hangzhou, Zhejiang, Peoples R China

[5] Shanghai Univ Tradit Chinese Med, Coll Pharm, Shanghai, Peoples R China

[6] Chengdu Univ, Sch Med, Chengdu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2020年 / 15卷

基金：

中国国家自然科学基金;

关键词：

glioma; brain barrier; nanoparticle drug delivery system; efficacy improvement strategies; deficiencies of NDDS; BLOOD-BRAIN-BARRIER; MESENCHYMAL STEM-CELLS; PH-SENSITIVE MICELLES; FUNCTIONALIZED NANOPARTICLES; POLYMERIC NANOPARTICLES; RESTRICTIVE RECEPTOR; ANTITUMOR EFFICACY; CELLULAR VEHICLES; BETA-ELEMENE; C6; GLIOMA;

D O I：

10.2147/IJN.S243223

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including bloodbrain barrier (BBB), blood-brain tumor barriers (BBTB), brain-cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.

引用

页码：2563 / 2582

页数：20

共 50 条

[31] Strategies for Enhanced Drug Delivery to the Central Nervous System
Dwibhashyam, V. S. N. M.
Nagappa, A. N.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 70 (02) : 145 - 153
[32] Paclitaxel loaded phospholipid-based gel as a drug delivery system for local treatment of glioma
Chen, Tijia
Gong, Ting
Zhao, Ting
Liu, Xing
Fu, Yao
Zhang, Zhirong
Gong, Tao
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 528 (1-2) : 127 - 132
[33] A Comprehensive Review on Microbubble Concept, Development and Its Application in Therapeutic Drug Delivery and Clinical Management of Disease
Rathor, Sandeep
Aamir, Sheikh
Bhatt, Dinesh C.
Kumar, Krishan
Kumar, Vikash
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021, 22 (11) : 1424 - 1443
[34] Brain Drug Delivery System: A Novel Review
Anitha, P.
Sowmyasree, G. Venkata
Samathoti, Prasanthi
Darwin, C. Ronald
Varma, P. M. M. Naga Lakshmi
Himabindu, A. V. S.
Latha, A. V. S. Madhu
Kumari, S. Sravana
Ashok, S.
Reddy, V. Sarovar
ASIAN JOURNAL OF PHARMACEUTICS, 2024, 18 (04) : 1036 - 1049
[35] Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies
Dhiman, Ashish
Rana, Dhwani
Benival, Derajram
Garkhal, Kalpna
THERAPEUTIC DELIVERY, 2025, 16 (01) : 87 - 115
[36] Advances in the use of chitosan and chlorotoxin- functionalized chitosan polymers in drug delivery and detection of glioma - A review
Wiranowska, Marzenna
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, 2024, 7
[37] Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery
Gao, Weiwei
Zhang, Yue
Zhang, Qiangzhe
Zhang, Liangfang
ANNALS OF BIOMEDICAL ENGINEERING, 2016, 44 (06) : 2049 - 2061
[38] Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
Tseng, Yuan-Yun
Chen, Tai-Yuan
Liu, Shih-Jung
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 16 : 4597 - 4614
[39] Strategies for drug delivery to the central nervous system by systemic route
Kasinathan, Narayanan
Jagani, Hitesh V.
Alex, Angel Treasa
Volety, Subrahmanyam M.
Rao, J. Venkata
DRUG DELIVERY, 2015, 22 (03) : 243 - 257
[40] Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review)
Huang, Yinghong
Cole, Susan P. C.
Cai, Tiange
Cai, Yu
ONCOLOGY LETTERS, 2016, 12 (01) : 11 - 15

← 1 2 3 4 5 →