Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

被引：127

作者：

Li, Jie ^{[1
,2
,3
,4
]}

Zhao, Jiaqian ^{[2
,3
,4
,5
]}

Tan, Tiantian ^{[2
,3
,4
]}

Liu, Mengmeng ^{[2
,3
,4
]}

Zeng, Zhaowu ^{[2
,3
,4
]}

Zeng, Yiying ^{[2
,3
,4
]}

Zhang, Lele ^{[6
]}

Fu, Chaomei ^{[1
]}

Chen, Dajing ^{[2
,3
,4
]}

Xie, Tian ^{[2
,3
,4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu, Sichuan, Peoples R China

[2] Hangzhou Normal Univ, Holist Integrat Pharm Inst, 1378 Wenyixi Rd, Hangzhou 311121, Zhejiang, Peoples R China

[3] Key Lab Elemene Class Anticanc Chinese Med Zhejia, Hangzhou, Zhejiang, Peoples R China

[4] Engn Lab Dev & Applicat Tradit Chinese Med Zhejie, Hangzhou, Zhejiang, Peoples R China

[5] Shanghai Univ Tradit Chinese Med, Coll Pharm, Shanghai, Peoples R China

[6] Chengdu Univ, Sch Med, Chengdu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2020年 / 15卷

基金：

中国国家自然科学基金;

关键词：

glioma; brain barrier; nanoparticle drug delivery system; efficacy improvement strategies; deficiencies of NDDS; BLOOD-BRAIN-BARRIER; MESENCHYMAL STEM-CELLS; PH-SENSITIVE MICELLES; FUNCTIONALIZED NANOPARTICLES; POLYMERIC NANOPARTICLES; RESTRICTIVE RECEPTOR; ANTITUMOR EFFICACY; CELLULAR VEHICLES; BETA-ELEMENE; C6; GLIOMA;

D O I：

10.2147/IJN.S243223

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including bloodbrain barrier (BBB), blood-brain tumor barriers (BBTB), brain-cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.

引用

页码：2563 / 2582

页数：20

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