Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

被引：15

作者：

Akinyemi, Rufus O. ^{[1
,2
,3
]}

Sarfo, Fred S. ^{[4
]}

Akinyemi, Joshua ^{[5
]}

Singh, Arti ^{[4
]}

Akpa, Matthew Onoja ^{[5
]}

Akpalu, Albert ^{[6
]}

Owolabi, Lukman ^{[7
]}

Adeoye, Abiodun M. ^{[1
,8
]}

Obiako, Reginald ^{[9
]}

Wahab, Kolawole ^{[10
]}

Sanya, Emmanuel ^{[10
]}

Komolafe, Morenikeji ^{[11
]}

Ogbole, Godwin ^{[12
]}

Fawale, Michael ^{[11
]}

Adebayo, Philip ^{[13
]}

Osaigbovo, Godwin ^{[14
]}

Sunmonu, Taofiki ^{[15
]}

Olowoyo, Paul ^{[16
]}

Chukwuonye, Innocent ^{[17
]}

Obiabo, Yahaya ^{[18
]}

Adeniji, Olaleye ^{[3
]}

Fakunle, Gregory ^{[8
]}

Melikam, Ezinne ^{[8
]}

Saulson, Raelle ^{[19
]}

Yaria, Joseph ^{[20
]}

Uwanruochi, Kelechi ^{[17
]}

Ibinaiye, Phillip ^{[9
]}

Amusa, Ganiyu Adeniyi ^{[14
]}

Yahaya, Isah Suleiman ^{[7
]}

Dambatta, Abdullahi Hamisu ^{[7
]}

Faniyan, Mercy ^{[8
]}

Olowoniyi, Peter ^{[17
]}

Bock-Oruma, Andrew ^{[18
]}

Joseph, Odo Chidi ^{[20
]}

Oguntade, Ayodipupo ^{[20
]}

Kolo, Philip ^{[10
]}

Laryea, Ruth ^{[6
]}

Lakoh, Sulaiman ^{[20
]}

Uvere, Ezinne ^{[8
]}

Farombi, Temitope ^{[20
]}

Akpalu, Josephine ^{[6
]}

Oyinloye, Olalekan ^{[10
]}

Appiah, Lambert ^{[4
]}

Calys-Tagoe, Benedict ^{[6
]}

Shidali, Vincent ^{[9
]}

Tabari, Nasir Abdulkadir ^{[7
]}

Adebayo, Oladimeji ^{[20
]}

Efidi, Richard ^{[20
]}

Adeleye, Osi ^{[3
]}

Owusu, Dorcas ^{[4
]}

机构：

[1] Univ Ibadan, Coll Med, Ctr Genom & Precis Med, Ibadan, Nigeria

[2] Univ Ibadan, Coll Med, Inst Adv Med Res & Training, Ibadan, Nigeria

[3] Fed Med Ctr, Abeokuta, Nigeria

[4] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana

[5] Univ Ibadan, Dept Epidemiol & Med Stat, Ibadan, Nigeria

[6] Univ Ghana, Dept Med, Accra, Ghana

[7] Bayero Univ, Aminu Kano Teaching Hosp, Kano, Nigeria

[8] Univ Ibadan, Coll Med, Dept Med, Ibadan, Nigeria

[9] Ahmadu Bello Univ, Dept Med, Teaching Hosp, Zaria, Nigeria

[10] Univ Ilorin, Dept Med, Teaching Hosp, Ilorin, Nigeria

[11] Obafemi Awolowo Univ, Dept Med, Teaching Hosp, Ife, Nigeria

[12] Univ Ibadan, Dept Radiol, Coll Med, Ibadan, Nigeria

[13] Ladoke Akintola Univ, Dept Med, Teaching Hosp, Ogbomosho, Nigeria

[14] Jos Univ, Dept Med, Teaching Hosp, Jos, Nigeria

[15] Fed Med Ctr, Dept Med, Owo, Nigeria

[16] Fed Univ, Dept Med, Teaching Hosp, Ido Ekiti, Nigeria

[17] Fed Med Ctr, Dept Med, Umuahia, Nigeria

[18] Delta State Univ, Dept Med, Teaching Hosp, Igharra, Nigeria

[19] Med Univ South Carolina, Dept Neurosci, Charleston, SC 29425 USA

[20] Univ Coll Hosp, Dept Med, Ibadan, Nigeria

[21] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA

[22] Univ Ibadan, Dept Hlth Promot & Educ, Ibadan, Nigeria

来源：

INTERNATIONAL JOURNAL OF STROKE | 2019年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

African; chronic disease; developing countries; genetic disorders; stroke; Sub-Saharan Africa; RISK-FACTORS; COGNITIVE IMPAIRMENT; INVESTIGATIVE RESEARCH; WARNING SIGNS; AWARENESS; SURVIVORS; POPULATION; PREDICTORS; DEPRESSION; GENOMICS;

D O I：

10.1177/1747493018790059

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25-1.81) and a family history of stroke (OR 1.20, 1.03-1.39) while Islamic religion (OR=0.82, CI: 0.72-0.94), being currently unmarried (OR = 0.81, CI: 0.70-0.92), and alcohol use (OR = 0.78, CI: 0.67-0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03-1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65-0.96). Conclusion To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

引用

页码：69 / 79

页数：11

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