Background It was not yet fully established whether the use of antiplatelet agents (APAs) is associated with an increased risk of colorectal post-polypectomy bleeding (PPB). Temporarily, discontinuation of APAs could reduce the risk of PPB, but at the same time, it could increase the risk of cardiovascular disease recurrence. This study aimed to assess the PPB risk in patients using APAs compared to patients without APAs or anticoagulant therapy who had undergone colonoscopy with polypectomy. Methods A systematic electronic search of the literature was performed using PubMed/MEDLINE, Scopus, and CENTRAL, to assess the risk of bleeding in patients who do not interrupt single antiplatelet therapy (P2Y12 inhibitors or aspirin) and undergone colonoscopy with polypectomy. Results Of 2417 identified articles, 8 articles (all of them were non-randomized studies of interventions (NRSI); no randomized controlled trials (RCT) were available on this topic) were selected for the meta-analysis, including 1620 patients on antiplatelet therapy and 13,321 controls. Uninterrupted APAs single therapy was associated with an increased risk of PPB compared to the control group (OR 2.31; CI 1.37-3.91). Patients on P2Y12i single therapy had a higher risk of both immediate (OR 4.43; CI 1.40-14.00) and delayed PPB (OR 10.80; CI 4.63-25.16) compared to the control group, while patients on aspirin single therapy may have a little to no difference increase in the number of both immediate and delayed PPB events. Conclusions Uninterrupted single antiplatelet therapy may increase the risk of PPB, but the evidence is very uncertain. The risk may be higher in delayed PPB. However, in deciding to discontinue APAs before colonoscopy with polypectomy, the potential higher risk of major adverse cardiovascular events should always be assessed.
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Li, De-Feng
Chang, Xin
论文数: 0引用数: 0
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Chang, Xin
Fang, Xue
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Fang, Xue
Wang, Jian-Yao
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Childrens Hosp, Dept Gen Surg, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Wang, Jian-Yao
Yu, Zhi-Chao
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h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Yu, Zhi-Chao
Wei, Cheng
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h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Wei, Cheng
Xiong, Feng
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机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Xiong, Feng
Xu, Zheng-Lei
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机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Xu, Zheng-Lei
Zhang, Ding-Guo
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Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Zhang, Ding-Guo
Liu, Ting-Ting
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Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Liu, Ting-Ting
Luo, Ming-Han
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机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Luo, Ming-Han
Wang, Li-Sheng
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Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Wang, Li-Sheng
Yao, Jun
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Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
机构:
Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Seton Dell Med Sch, Stroke Inst, Dept Neurol, 1400 N IH 35 Suite C3-400, Austin, TX 78701 USADell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Milling, Truman J., Jr.
Ziebell, Christopher M.
论文数: 0引用数: 0
h-index: 0
机构:
Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USADell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Li, De-Feng
Chang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Chang, Xin
Fang, Xue
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Fang, Xue
Wang, Jian-Yao
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Childrens Hosp, Dept Gen Surg, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Wang, Jian-Yao
Yu, Zhi-Chao
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Yu, Zhi-Chao
Wei, Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Wei, Cheng
Xiong, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Xiong, Feng
Xu, Zheng-Lei
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Xu, Zheng-Lei
Zhang, Ding-Guo
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Zhang, Ding-Guo
Liu, Ting-Ting
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Liu, Ting-Ting
Luo, Ming-Han
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Luo, Ming-Han
Wang, Li-Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
Wang, Li-Sheng
Yao, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R ChinaJinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China
机构:
Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Seton Dell Med Sch, Stroke Inst, Dept Neurol, 1400 N IH 35 Suite C3-400, Austin, TX 78701 USADell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Milling, Truman J., Jr.
Ziebell, Christopher M.
论文数: 0引用数: 0
h-index: 0
机构:
Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USADell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA