Inhibition of fibrillation of lysozyme by folic acid functionalized cerium oxide nanoparticle

被引：0
作者：
Samai, Boby [1 ]
Mati, Soumya Sundar [2 ]
Bhattacharya, Subhash Chandra [1 ]
机构：
[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India
[2] Govt Gen Degree Coll, Paschim Medinipur 721135, W Bengal, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2018年 / 95卷 / 08期
关键词：
Fibrillation; lysozyme; cerium oxide; nanoparticle; AMYLOID FIBRILS; PROTEIN; DISEASES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Effect of folic acid functionalized nanoceria on fibrillation of lysozyme has been studied using spectroscopic and microscopic tools. Both bare and functionalized CeONP are capable to retard fibrillation of lysozyme. Also interaction of lysozyme with nanoceria has been studied employing multiple biophysical techniques. The intrinsic fluorescence of lysozyme is quenched in presence of nanoceria. Adsorption of lysozyme causes significant reduction on fibrillization of lysozyme. Mechanism of quenching has been interpreted.
引用
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页码：945 / 949
页数：5
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