Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice

被引：22

作者：

Shin, Eun-Joo ^{[1
]}

Jeong, Ji Hoon ^{[2
]}

Kim, Hyun Ji ^{[1
]}

Jang, Choon-Gon ^{[3
]}

Yamada, Klyofumi ^{[4
]}

Nabeshima, Toshitaka ^{[4
,5
]}

Kim, Hyoung-Chun ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 200701, South Korea

[2] Chung Ang Univ, Coll Med, Dept Pharmacol, Seoul 156756, South Korea

[3] Sungkyunkwan Univ, Coll Pharm, Dept Pharmacol, Suwon 400746, South Korea

[4] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4668560, Japan

[5] Meijo Univ, Grad Sch Pharmaceut Sci, Dept Chem Pharmacol, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2007年 / 105卷 / 04期

关键词：

extremely low frequency magnetic field; locomotor activity; dopaminergic receptor;

D O I：

10.1254/jphs.SC0070348

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D-1-like receptor antagonist, but not with sulpiride, a. dopaminergic D-2-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D-1-like receptors.

引用

页码：367 / 371

页数：5

共 15 条

[1] Effects of extremely low frequency magnetic field on fertility of adult male and female rats [J].