SNAPPE II Score As a Predictor of Survival in Neonates with Congenital Diaphragmatic Hernia: A Single Center Experience
被引:8
作者:
Chiu, Louisa W.
论文数: 0引用数: 0
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机构:
Childrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Baylor Coll Med, Dept Surg, Houston, TX 77030 USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Chiu, Louisa W.
[1
,2
]
Desai, Jagdish
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h-index: 0
机构:
Wayne State Univ, Childrens Hosp Michigan, Dept Pediat, Div Neonatal Perinatal Med, Detroit, MI USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Desai, Jagdish
[3
]
Shanti, Christina
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机构:
Childrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Shanti, Christina
[1
]
Rane, Sharayu
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Childrens Hosp Michigan, Dept Pediat, Div Neonatal Perinatal Med, Detroit, MI USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Rane, Sharayu
[3
]
Agarwal, Prashant
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机构:
Wayne State Univ, Childrens Hosp Michigan, Dept Pediat, Div Neonatal Perinatal Med, Detroit, MI USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Agarwal, Prashant
[3
]
Thomas, Ronald Lee
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机构:
Wayne State Univ, Dept Biostat, Childrens Res Ctr Michigan, Detroit, MI USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Thomas, Ronald Lee
[4
]
Klein, Michael
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机构:
Childrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USAChildrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
Klein, Michael
[1
]
论文数: 引用数:
h-index:
机构:
Chouthai, Nitin Shashikant
[3
]
机构:
[1] Childrens Hosp Michigan, Dept Pediat Surg, Detroit, MI 48201 USA
[2] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA
[3] Wayne State Univ, Childrens Hosp Michigan, Dept Pediat, Div Neonatal Perinatal Med, Detroit, MI USA
[4] Wayne State Univ, Dept Biostat, Childrens Res Ctr Michigan, Detroit, MI USA
congenital diaphragmatic hernia;
predictors of mortality;
SNAPPE II score;
EXTRACORPOREAL MEMBRANE-OXYGENATION;
FREQUENCY OSCILLATORY VENTILATION;
ULTRASOUND DIAGNOSIS;
ANTENATAL DIAGNOSIS;
PROGNOSTIC VALUE;
DELAYED REPAIR;
BIRTH-WEIGHT;
HIGH-RISK;
MORTALITY;
INFANTS;
D O I:
10.1055/s-0035-1554103
中图分类号:
R72 [儿科学];
学科分类号:
100202 ;
摘要:
Introduction Prediction of mortality and morbidity in newborns with congenital diaphragmatic hernia (CDH) is too complex for practical use and may not be accurate. The main objective of this study was to evaluate the usefulness of the CDH Study Group equation and Score of Neonatal Acute Physiology Perinatal Extension (SNAPPE) II score to predict short-term outcomes of newborns with CDH. Materials and Methods Fifty-two neonates were admitted with CDH at Children's Hospital of Michigan from November 2001 to July 2009. Retrospective chart analysis was performed. Predicted survival rates were calculated using the equation published by the CDH Study Group in 2001. SNAPPE II scores were also obtained within 12 hours of admission. Statistical analysis was performed using SPSS statistical package. Results Thirty out of 52 (58%) neonates survived to discharge. SNAPPE II score was significantly lower (p < 0.0001) in survivors (20 +/- 15) versus nonsurvivors (41 +/- 16). When neonates were stratified according to the CDH Study Group, low-risk patients had a survival rate of 68% (predicted 84%), moderate-risk patients had a survival rate of 43% (predicted 57%), and high-risk patients had a survival rate of 33% (predicted 36%). A total of 83% of the newborns who survived were operated within 48 hours of life, while only 17% of the nonsurvivors were operated within 48 hours of life. Conclusion SNAPPE II scores were better predictors of mortality than the CDH Study Group equation published in 2001. Further exploration is warranted to evaluate validity of survival advantage for those who were operated within 48 hours of life. A future study of combination of prenatal and postnatal factors may help in improved outcomes of the newborns with CDH.