Are women with Sjogren's syndrome androgen-deficient?

被引:0
作者
Sullivan, DA
Bélanger, A
Cermak, JM
Bérubé, R
Papas, AS
Sullivan, RM
Yamagami, H
Dana, MR
Labrie, F
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Schepens Eye Res Inst, Boston, MA 02115 USA
[2] Tufts Univ, Sch Dent Med, Boston, MA 02111 USA
[3] Univ Laval, Ctr Hosp, Res Ctr, Mol Endocrinol Lab, Quebec City, PQ, Canada
关键词
Sjogren's syndrome; androgens; estrogens; dry eye;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. We hypothesize that androgen deficiency is a critical etiologic factor in the pathogenesis of aqueous-deficient and evaporative dry eye in Sjogren's syndrome (SS). We investigated whether women with SS have a deficiency in total androgens. We also examined whether these patients have elevated serum concentrations of estrogens. Methods. Blood was drawn from women with primary and secondary SS and age matched controls, and analyzed for steroid concentrations by gas and liquid chromatography-mass spectrometry. Results. Our results show that women with SS are androgen-deficient. Concentrations of 5-androstene.-3beta-diol (5-diol), dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), androsterone-glucuronide (ADT-G), and androstane-3alpha,17beta-diol-G (3alpha-diol-G) were all significantly reduced in SS sera relative to controls. In contrast, SS was not associated with significant alterations in the serum concentrations of testosterone, androstenedione, estrone, or 17beta-estradiol. These overall findings could not be attributed to the use of oral contraceptives or hormone replacement therapy, because the concentrations of 5-diol, DHEA, DHT, ADT-G and 3a-diol-G were also decreased in patients with SS compared to levels in control women who were not taking exogenous estrogens. Conclusion. Our results show that women with SS are androgen-deficient.
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页码:2413 / 2419
页数:7
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