Selection of nonnucleoside reverse transcriptase inhibitor-associated mutations in HIV-1 subtype C: evidence of etravirine cross-resistance

被引：19

作者：

Neogi, Ujjwal ^{[2
,3
,4
]}

Shet, Anita ^{[2
,4
]}

Shamsundar, Ranjani ^{[2
]}

Ekstrand, Maria L. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Ctr AIDS Prevent Studies, Dept Med, San Francisco, CA 94105 USA

[2] St Johns Natl Acad Hlth Sci, Bangalore, Karnataka, India

[3] Karolinska Inst, Dept Med, Stockholm, Sweden

[4] Karolinska Inst, Div Global Hlth, Stockholm, Sweden

来源：

AIDS | 2011年 / 25卷 / 08期

关键词：

EXPERIENCED HIV-1-INFECTED PATIENTS; PLACEBO-CONTROLLED TRIAL; DRUG-RESISTANCE; ANTIRETROVIRAL THERAPY; TMC125; ETRAVIRINE; INDIAN PATIENTS; DOUBLE-BLIND; B HIV-1; NEVIRAPINE; NAIVE;

D O I：

10.1097/QAD.0b013e328346269f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prevalence of etravirine genotypic resistance was assessed among 92 HIV-1C-infected patients failing nevirapine and efavirenz-based regimens from a cohort of 552 Indian patients. Overall, prevalence of etravirine cross-resistance identified using the Tibotec Weighted Score was 41% (31.5% intermediately-resistant and 9.8% fully-resistant). The most frequently described nonnucleoside reverse transcriptase inhibitor-associated mutations included Y181 (35.9%), K101 (20.7%), G190 (17.4%), and V108 (15.2%). The resistant group demonstrated higher viral load (P = 0.01) and longer duration of antiretroviral treatment (P = 0.03) compared with the susceptible group.

引用

页码：1123 / 1126

页数：4

共 27 条

[1]

Benhamida J, 2008, ANTIVIR THER, V13, pA142

[2]

BUNUPURADAH T, 2010, 18 INT AIDS C VIENN

[3] Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study [J].

Choudhury, Shubhasree Dutta ;

Chaudhury, Alok K. ;

Kalra, Rajesh ;

Andrabi, Raiees ;

Wig, Naveet ;

Biswas, Ashutosh ;

Bala, Manju ;

Luthra, Kalpana .

ARCHIVES OF VIROLOGY, 2010, 155 (04) :563-569

[4] Resistance mutations in subtype CHIV type 1 isolates from Indian patients of mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: Resistance to AR [J].

Deshpande, Alaka ;

Jauvin, Valerie ;

Magnin, Noel ;

Pinson, Patricia ;

Faure, Muriel ;

Masquelier, Bernard ;

Aurillac-Lavignolle, Valerie ;

Fleury, Herve J. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (02) :335-340

[5] Developing Useful Highly Active Antiretroviral Therapy Adherence Measures for India: The Prerana Study [J].

Ekstrand, Maria L. ;

Chandy, Sara ;

Heylen, Elsa ;

Steward, Wayne ;

Singh, Girija .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 53 (03) :415-417

[6]

EKSTRAND ML, 2010, 18 INT AIDS C VIENN

[7]

Johnson Victoria A, 2008, Top HIV Med, V16, P138

[8]

Joly V, 2000, ANN MED INTERNE, V151, P260

[9] Drug resistant mutations detected by genotypic drug resistance testing in patients failing therapy in clade C HIV-1 infected individuals from India [J].

Kandathil, A. J. ;

Kannangai, R. ;

Verghese, V. P. ;

Pulimood, S. A. ;

Rupali, P. ;

Sridharan, G. ;

Grant, P. ;

Pillay, D. ;

Abraham, O. C. .

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2009, 27 (03) :231-236

[10]

Lapadula G, 2008, ANTIVIR THER, V13, P601

← 1 2 3 →