[1] Univ Birmingham, Birmingham Acute Care Res Grp, Inst Inflammat & Ageing, Birmingham, W Midlands, England
[2] Univ Birmingham, Inst Metab & Syst Res, Birmingham, W Midlands, England
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Anaesthesia, San Francisco, CA 94143 USA
[5] Univ Warwick, Warwick Med Sch, Prehosp Emergency Perioperat & Crit Care Grp, Warwick, England