The TPH intron 7 A218C polymorphism and TO dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology

被引：13
作者：
Anghelescu, I
Klawe, C
Fehr, C
Singer, P
Schleicher, A
Himmerich, H
Hiemke, C
Dahmen, N
Szegedi, A
机构：
[1] Univ Med Berlin, Dept Psychiat & Psychotherapy, Charite, D-14050 Berlin, Germany
[2] Johannes Gutenberg Univ Mainz, Dept Psychiat, D-55101 Mainz, Germany
[3] Max Planck Inst Psychiat, D-80804 Munich, Germany
来源：
ADDICTIVE BEHAVIORS | 2005年 / 30卷 / 06期
关键词：
psychiatric genetics; alcoholism; tryptophan hydroxylase; polymorphisms; temperament and character inventory; serotonin;
D O I：
10.1016/j.addbeh.2004.11.002
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
Aims: A linkage of certain alleles of the tryptophan hydroxylase (TPH) intron 7 A218C polymorphism. to suicidality and antisocial behaviour has been described. The aim of our study was to find any association between dimensions of the Temperament and Character Inventory (TCI) indicating impulsivity and the TPH polymorphism alleles in unselected alcohol-dependent patients and age-matched controls. Methods: We examined 159 alcohol-dependent patients and 161 controls with the TO and genotyped them for the TPH intron 7 A218C polymorphism alleles. Results: Although homozygous TPH genotypes were found more often in alcohol-dependent patients than in controls, an association between TO dimensions and TPH alleles was not observed in the complete sample. Alcohol-dependent patients, however, scored significantly higher for harm avoidance (HA) and lower for self-directedness (SD) than controls regardless of TPH genotype. Among controls, for those with the A/A genotype, harm avoidance was as high as in the group of alcohol-dependent patients, persistence (P) in that genotype was significantly lower than for all other genotypes in the patient and control group. Conclusion: Even if there is no association between TO dimensions and TPH genotype in our sample, hints to nonspecific psychopathology in connection with the A/A genotype are found. (c) 2004 Elsevier Ltd. All rights reserved.
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页码：1135 / 1143
页数：9
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