Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value

被引:54
作者
Atzeni, Fabiola [1 ]
Doria, Andrea [2 ]
Ghirardello, Anna [2 ]
Turiel, Maurizio [3 ]
Batticciotto, Alberto [1 ]
Carrabba, Mario [1 ]
Sarzi-Puttini, Piercarlo [1 ]
机构
[1] Univ Hosp L Sacco, Rheumatol Unit, I-20157 Milan, Italy
[2] Univ Padua, Chair Rheumatol, Padua, Italy
[3] Univ Milan, Ist Ortopedico Galeazzi, IRCCS, Dept Cardiol, Milan, Italy
关键词
anti-thyroid antibodies; organ-specific antibodies; rheumatoid arthritis; autoimmune thyroid disease;
D O I
10.1080/08916930701620100
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: The aim of this study was to assess thyroid function as well as the prevalence and clinical value of anti-thyroid antibodies in patients with rheumatoid arthritis (RA). Methods: Seventy patients with active RA (ACR criteria), 9 males and 61 females, mean age 47 years (range 15-77) were analyzed. Anti-thyroperoxidase (TPOAb) and anti-thyroglobulin antibodies (TgAb) were tested using radioimmunoassay. Free thyroxine (FT4) and free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH) serum levels were measured using electro-immunochemiluminescence (ECLIA, Elecsys Roche). Clinical variables, including tender and swollen joint count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP) and antinuclear antibodies (ANA) were also evaluated. Statistics were performed by the SPSS statistical software for Windows. Results: Twenty-six patients (37%) with RA were positive for TPOAb and 16 (23%) for TgAb. In 5 (7.1%) patients TSH level was slightly elevated, ranging between 4.52 and 15.65UI/ml. The increase of TSH levels was associated with normal FT4 in 3 cases (4.2%) and with reduced FT4 in 2 cases (2.8%). One patient (1.5%) had low TSH serum value along with normal FT4. No differences in clinical and serological data between anti-thyroid positive and negative patients were observed. Conclusion: Our study shows an increased prevalence of anti-thyroid antibodies in RA patients with a low prevalence of hormonal alterations. However, anti-thyroid antibodies do not seem to identify any peculiar RA phenotype.
引用
收藏
页码:111 / 115
页数:5
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