Research Progress of NMR in Natural Product Quantification

被引：54
作者：
Wang, Zhi-Fan [1 ]
You, Yu-Lin [1 ]
Li, Fei-Fei [1 ]
Kong, Wen-Ru [1 ]
Wang, Shu-Qi [1 ]
机构：
[1] Shandong Univ, Sch Pharm Sci, 44 West Wenhua Rd, Jinan 250012, Peoples R China
来源：
MOLECULES | 2021年 / 26卷 / 20期
关键词：
quantitative nuclear magnetic resonance (qNMR); natural products; quantitative analysis; NUCLEAR-MAGNETIC-RESONANCE; SOLID-STATE NMR; QUANTITATIVE H-1-NMR METHOD; 2D NMR; LEONURUS JAPONICUS; MEMBRANE-PROTEINS; RHIZOMA-COPTIDIS; QUALITY-CONTROL; ESSENTIAL OILS; SPECTROSCOPY;
D O I：
10.3390/molecules26206308
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the fields of medicine and health, traditional high-performance liquid chromatography or UV-visible spectrophotometry is generally used for substance quantification. However, over time, nuclear magnetic resonance spectroscopy (NMR) has gradually become more mature. Nuclear magnetic resonance spectroscopy has certain advantages in the quantitative analysis of substances, such as being nondestructive, having a high flux and short analysis time. Nuclear magnetic resonance spectroscopy has been included in the pharmacopoeiae of various countries. In this paper, the principle of nuclear magnetic resonance spectroscopy and the recent progress in the quantitative study of natural products by NMR are reviewed, and its application in the quantitative study of natural products is proposed. At the same time, the problems of using NMR alone to quantify natural products are summarized and corresponding suggestions are put forward.</p>
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页数：17
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