Research Progress of NMR in Natural Product Quantification

被引：54
作者：
Wang, Zhi-Fan [1 ]
You, Yu-Lin [1 ]
Li, Fei-Fei [1 ]
Kong, Wen-Ru [1 ]
Wang, Shu-Qi [1 ]
机构：
[1] Shandong Univ, Sch Pharm Sci, 44 West Wenhua Rd, Jinan 250012, Peoples R China
来源：
MOLECULES | 2021年 / 26卷 / 20期
关键词：
quantitative nuclear magnetic resonance (qNMR); natural products; quantitative analysis; NUCLEAR-MAGNETIC-RESONANCE; SOLID-STATE NMR; QUANTITATIVE H-1-NMR METHOD; 2D NMR; LEONURUS JAPONICUS; MEMBRANE-PROTEINS; RHIZOMA-COPTIDIS; QUALITY-CONTROL; ESSENTIAL OILS; SPECTROSCOPY;
D O I：
10.3390/molecules26206308
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the fields of medicine and health, traditional high-performance liquid chromatography or UV-visible spectrophotometry is generally used for substance quantification. However, over time, nuclear magnetic resonance spectroscopy (NMR) has gradually become more mature. Nuclear magnetic resonance spectroscopy has certain advantages in the quantitative analysis of substances, such as being nondestructive, having a high flux and short analysis time. Nuclear magnetic resonance spectroscopy has been included in the pharmacopoeiae of various countries. In this paper, the principle of nuclear magnetic resonance spectroscopy and the recent progress in the quantitative study of natural products by NMR are reviewed, and its application in the quantitative study of natural products is proposed. At the same time, the problems of using NMR alone to quantify natural products are summarized and corresponding suggestions are put forward.</p>
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页数：17
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共 160 条
[1]   Silybum marianum pericarp yields enhanced silymarin products [J].
AbouZid, Sameh F. ;
Chen, Shao-Nong ;
McAlpine, James B. ;
Friesen, J. Brent ;
Pauli, Guido F. .
FITOTERAPIA, 2016, 112 :136-143
[2]   Silymarin content in Silybum marianum populations growing in Egypt [J].
AbouZid, Sameh F. ;
Chen, Shao-Nong ;
Pauli, Guido F. .
INDUSTRIAL CROPS AND PRODUCTS, 2016, 83 :729-737
[3]   Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis [J].
Aguilar, Juan A. ;
Cassani, Julia ;
Probert, Fay ;
Palace, Jacqueline ;
Claridge, Tim D. W. ;
Botana, Adolfo ;
Kenwright, Alan M. .
ANALYST, 2019, 144 (24) :7270-7277
[4]   Laceioside, a new cycloartane saponin from Astragalus tephrosioides Boiss. var. lacei (Ali) Kirchoff. [J].
Ahmad, Viqar Uddin ;
Mohammad, Faryal Vali ;
Tareen, Rasool Bakhsh .
NATURAL PRODUCT RESEARCH, 2019, 33 (03) :393-399
[5]   A multivariate approach to investigate the NMR CPMG pulse sequence for analysing low MW species in polymers [J].
Aiello, Federica ;
Gerretzen, Jan ;
Simons, Marcel G. ;
Davies, Antony N. ;
Dani, Paulo .
MAGNETIC RESONANCE IN CHEMISTRY, 2021, 59 (02) :172-186
[6]   Concentration measurement by proton NMR using the ERETIC method [J].
Akoka, S ;
Barantin, L ;
Trierweiler, M .
ANALYTICAL CHEMISTRY, 1999, 71 (13) :2554-2557
[7]   Evaluation of the ERETIC Method as an Improved Quantitative Reference for 1H HR-MAS Spectroscopy of Prostate Tissue [J].
Albers, Mark J. ;
Butler, Thomas N. ;
Rahwa, Iman ;
Bao, Nguyen ;
Keshari, Kayvan R. ;
Swanson, Mark G. ;
Kurhanewicz, John .
MAGNETIC RESONANCE IN MEDICINE, 2009, 61 (03) :525-532
[8]   Solid-State Nuclear Magnetic Resonance in Pharmaceutical Compounds [J].
Alberto Monti, Gustavo ;
Karina Chattah, Ana ;
Garro Linck, Yamila .
ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 83, 2014, 83 :221-269
[9]   ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF MEGASTIGMANE GLYCOSIDES FROM Hosta plantaginea [J].
Bao, Xiao-hua ;
Wang, Qing-hu ;
Bao, Bai-yinmu-qi-er ;
Han, Jing-jing ;
Ao, Wu-li-ji .
CHEMISTRY OF NATURAL COMPOUNDS, 2017, 53 (04) :614-617
[10]   A new method for absolute quantitation of MRS metabolites [J].
Barantin, L ;
LePape, A ;
Akoka, S .
MAGNETIC RESONANCE IN MEDICINE, 1997, 38 (02) :179-182
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