The effect of ring size of fused chelates on the stability constants and spectroscopic properties of nickel(II) and palladium(II) complexes of peptides

被引：19

作者：

Agoston, CG ^{[1
]}

Miskolczy, Z ^{[1
]}

Nagy, Z ^{[1
]}

Sóvágó, I ^{[1
]}

机构：

[1] Univ Debrecen, Dept Inorgan & Analyt Chem, H-4010 Debrecen, Hungary

来源：

POLYHEDRON | 2003年 / 22卷 / 18期

基金：

匈牙利科学研究基金会;

关键词：

beta-alanine; dipeptides; tripeptides; nickel(II); palladium(II); stability constants;

D O I：

10.1016/S0277-5387(03)00367-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nickel(II) and palladium(II) complexes of di- and tri-peptides containing beta-alanyl residues have been studied by potentiometric, UV-Vis and NMR spectroscopic methods. Coordination geometries of the metal ions were not affected by the chelate ring size, but the thermodynamic stability of the complexes was significantly influenced by the number and location of beta-alanyl residues. The destabilizing effect of the N-terminal beta-alanyl moieties was observed in all cases. The stability order for the (NH2, N-, N-, COO-) coordination mode of [NiH-2L](-) complexes is described as follows: GlyGly-beta-Ala (5,5,6) greater than or equal to Gly-beta-AlaGly (5,6,5) greater than or equal to GlyGlyGly (5,5,5) > beta-AlaGlyGly (6,5,5) > Gly-beta-Ala-beta-Ala (5,6,6) > beta-AlaGly-beta-Ala (6,5,6), while for the corresponding palladium(II) complexes: Gly-beta-AlaGly (5,6,5) > GlyGly-beta-Ala (5,5,6) > Gly-beta-Ala-beta-Ala (5,6,6) > GlyGlyGly (5,5,5) > beta-AlaGly-beta-Ala (6,5,6) greater than or equal to beta-AlaGlyGly (6,5,5). The data suggest that the inclusion of beta-alanine into the internal or C-terminal positions of tripeptide molecules significantly enhances the metal binding ability of the ligands. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2607 / 2615

页数：9

共 22 条

[11] A STUDY OF SOME PROBLEMS IN DETERMINING STOICHEIOMETRIC PROTON DISSOCIATION CONSTANTS OF COMPLEXES BY POTENTIOMETRIC TITRATIONS USING A GLASS ELECTRODE [J].

IRVING, HM ;

MILES, MG ;

PETTIT, LD .

ANALYTICA CHIMICA ACTA, 1967, 38 (04) :475-+

[12] CONFORMATION AND SOLUTION EQUILIBRIA OF DIASTEREOISOMERIC DIPEPTIDES AND THEIR COPPER(II) AND NICKEL(II) COMPLEXES [J].

KANEDA, A ;

MARTELL, AE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (05) :1586-1593

[13]

Leggett DJ, 1985, Computational Methods for the Determination of Formation Constants

[14] THE ASSOCIATION OF NICKEL(II) ION WITH PEPTIDES [J].

MARTIN, RB ;

CHAMBERLIN, M ;

EDSALL, JT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (02) :495-498

[15] The effect of the ring size of fused chelates on the thermodynamic and spectroscopic properties of peptide complexes of copper(II) [J].

Sanna, D ;

Agoston, CG ;

Micera, G ;

Sóvágó, I .

POLYHEDRON, 2001, 20 (26-27) :3079-3090

[16] COORDINATING PROPERTIES OF THE AMIDE BOND - STABILITY AND STRUCTURE OF METAL-ION COMPLEXES OF PEPTIDES AND RELATED LIGANDS [J].

SIGEL, H ;

MARTIN, RB .

CHEMICAL REVIEWS, 1982, 82 (04) :385-426

[17] TERNARY COMPLEXES IN SOLUTION .36. STABILITY OF BINARY AND TERNARY BETA-ALANINE CONTAINING DIPEPTIDE COPPER(II) COMPLEXES [J].

SIGEL, H ;

PRIJS, B ;

MARTIN, RB .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1981, 56 (02) :45-49

[18]

Sovago I., 1990, Biocoordination Chemistry

[19]

Varnagy K, 1998, INORG CHIM ACTA, V276, P440

[20] Circular Dichroism of Palladium(II) Complexes of Amino Acids and Peptides [J].

Wilson, Edmond W., Jr. ;

Martin, R. Bruce .

INORGANIC CHEMISTRY, 1970, 9 (03) :528-532

← 1 2 3 →