Quercetin Attenuates High-Fat Diet-Induced Excessive Fat Deposition of Spotted Seabass (Lateolabrax maculatus) Through the Regulatory for Mitochondria and Endoplasmic Reticulum

被引：23

作者：

Dong, Yan-Zou ^{[1
]}

Xia, Tian ^{[1
]}

Lin, Ji-Bin ^{[1
]}

Wang, Ling ^{[1
]}

Song, Kai ^{[1
]}

Zhang, Chun-Xiao ^{[1
]}

机构：

[1] Jimei Univ, Fisheries Coll, Key Lab Feed Qual Testing & Safety, Xiamen, Peoples R China

来源：

FRONTIERS IN MARINE SCIENCE | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

Lateolabrax maculatus; fatty liver; mitochondrial biogenesis; mitophagy; endoplasmic reticulum stress; BREAM MEGALOBRAMA-AMBLYCEPHALA; OXIDATIVE STRESS; LIVER-DISEASE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; ACCUMULATION; HEPATOCYTES; ANTIOXIDANT; DYSFUNCTION;

D O I：

10.3389/fmars.2021.746811

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study aimed to investigate the effects of quercetin (QUE) on fat deposition and the underlying mechanism. Fish were fed four test diets: normal fat diet (NFD), high-fat diet (HFD), and HFD supplemented with 0.5 or 1.0 g/kg quercetin (QUE0.5 or QUE1.0). The results showed that HFD feeding resulted in poor growth and feed utilization while QUE treatment reversed this. The fat contents of serum and liver were increased by HFD and QUE supplementation significantly decreased fat content. Furthermore, gene expressions and ultrastructure observation showed that mitochondrial biogenesis and mitophagy were inhibited and endoplasmic reticulum stress (ERS) in the HFD group. QUE can activate the biogenesis and autophagy of mitochondria and suppress ERS, which is related to its fat-lowering effect.</p>

引用

页数：9

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