Myocardial ischemia and coronary disease in heart failure

被引：247

作者：

Pagliaro, Beniamino R. ^{[1
]}

Cannata, Francesco ^{[1
,2
]}

Stefanini, Giulio G. ^{[1
,2
]}

Bolognese, Leonardo ^{[3
]}

机构：

[1] IRCCS, Humanitas Clin & Res Ctr, Rozzano, Milan, Italy

[2] Humanitas Univ, Dept Biomed Sci, Via R Levi Montalcini 4, 20090 Pieve Emanuele, I-20090 Milan, Italy

[3] Osped San Donato, Dipartimento Cardio Neuro Vascolare, Arezzo, Italy

来源：

HEART FAILURE REVIEWS | 2020年 / 25卷 / 01期

关键词：

Heart failure; Coronary artery disease; Myocardial ischemia; Wall stress; Microvascular dysfunction; INTRAAORTIC BALLOON COUNTERPULSATION; MECHANICAL CIRCULATORY SUPPORT; ANGIOTENSIN-ALDOSTERONE SYSTEM; ARTERY-BYPASS SURGERY; MICROVASCULAR DYSFUNCTION; CARDIOGENIC-SHOCK; HEMODYNAMIC SUPPORT; MEDICAL PROGRESS; CONTROLLED-TRIAL; FLOW-RESERVE;

D O I：

10.1007/s10741-019-09831-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is a complex clinical syndrome and represents the final path of numerous heart diseases. Coronary artery disease is recognized as the primary risk factor for heart failure development, being the main etiological factor in more than 50% of heart failure patients in North America and Europe. Regardless of overt coronary artery disease, myocardial ischemia is a common finding in failing hearts, likely due to structural or functional coronary circulation alterations. Ischemia is a self-propagating process which irreversibly impairs the cardiac function and negatively impacts prognosis. Thus, a better and thorough understanding of myocardial ischemia pathophysiology in heart failure would likely lead to significantly improved outcomes in these patients. This review aims to describe the mechanisms of myocardial ischemia and coronary artery disease in heart failure, focusing on coronary circulation dysfunctions due to increased parietal stress or non-obstructive coronary disease, and discussing the association and management of coronary artery disease in patients with heart failure.

引用

页码：53 / 65

页数：13

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