Circulating and Intracellular miRNAs as Prognostic and Predictive Factors in HER2-Positive Early Breast Cancer Treated with Neoadjuvant Chemotherapy: A Review of the Literature

被引：11

作者：

Isca, Chrystel ^{[1
]}

Piacentini, Federico ^{[1
]}

Mastrolia, Ilenia ^{[2
]}

Masciale, Valentina ^{[2
]}

Caggia, Federica ^{[1
]}

Toss, Angela ^{[1
]}

Piombino, Claudia ^{[1
]}

Moscetti, Luca ^{[3
]}

Barbolini, Monica ^{[1
]}

Maur, Michela ^{[3
]}

Dominici, Massimo ^{[1
,2
]}

Omarini, Claudia ^{[3
]}

机构：

[1] Univ Hosp Modena, Div Med Oncol, Dept Med & Surg Sci Children & Adults, I-41124 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Med & Surg Sci, Lab Cellular Therapy, I-41124 Modena, Italy

[3] Univ Hosp Modena, Dept Hematol Oncol, Div Med Oncol, I-41124 Modena, Italy

来源：

CANCERS | 2021年 / 13卷 / 19期

关键词：

exosome; miRNA; extracellular vesicles; HER2 positive breast cancer; early stage breast cancer; neoadjuvant chemotherapy; trastuzumab; predictive factors; prognostic factors; PLUS ADJUVANT CHEMOTHERAPY; TRASTUZUMAB EMTANSINE; UP-REGULATION; CELL-GROWTH; OPEN-LABEL; EXPRESSION; RESISTANCE; MICRORNAS; INVASION; MIGRATION;

D O I：

10.3390/cancers13194894

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNA) are small noncoding RNAs that can act as both oncogene and tumor suppressors. Deregulated miRNA expression has been detected in human cancers, including breast cancer (BC). Considering their important roles in tumorigenesis, miRNAs have been investigated as potential prognostic and diagnostic biomarkers. Neoadjuvant setting is an optimal model to investigate in vivo the mechanism of treatment resistance. In the management of human epidermal growth factor receptor-2 (HER2)-positive early BC, the anti-HER2-targeted therapies have drastically changed the survival outcomes. Despite this, growing drug resistance due to the pressure of therapy is relatively frequent. In the present review, we focused on the main miRNAs involved in HER2-positive BC tumorigenesis and discussed the recent evidence on their predictive and prognostic value.

引用

页数：13

共 119 条

[1] MicroRNA-376b promotes breast cancer metastasis by targeting Hoxd10 directly [J].

An, Ning ;

Luo, Xinmei ;

Zhang, Ming ;

Yu, Ruilian .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 13 (01) :79-84

[2] Good guy or bad guy: the opposing roles of microRNA 125b in cancer [J].

Banzhaf-Strathmann, Julia ;

Edbauer, Dieter .

CELL COMMUNICATION AND SIGNALING, 2014, 12

[3] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[4] Biogenesis and function of extracellular vesicles in cancer [J].

Bebelman, Maarten P. ;

Smit, Martine J. ;

Pegtel, D. Michiel ;

Baglio, S. Rubina .

PHARMACOLOGY & THERAPEUTICS, 2018, 188 :1-11

[5] MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11 [J].

Bockhorn, Jessica ;

Dalton, Rachel ;

Nwachukwu, Chika ;

Huang, Simo ;

Prat, Aleix ;

Yee, Kathy ;

Chang, Ya-Fang ;

Huo, Dezheng ;

Wen, Yujia ;

Swanson, Kaitlin E. ;

Qiu, Tyler ;

Lu, Jun ;

Park, Seo Young ;

Dolan, M. Eileen ;

Perou, Charles M. ;

Olopade, Olufunmilayo I. ;

Clarke, Michael F. ;

Greene, Geoffrey L. ;

Liu, Huiping .

NATURE COMMUNICATIONS, 2013, 4

[6] 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial [J].

Cameron, David ;

Piccart-Gebhart, Martine J. ;

Gelber, Richard D. ;

Procter, Marion ;

Goldhirsch, Aron ;

de Azambuja, Evandro ;

Castro, Gilberto, Jr. ;

Untch, Michael ;

Smith, Ian ;

Gianni, Luca ;

Baselga, Jose ;

Al-Sakaff, Nedal ;

Lauer, Sabine ;

McFadden, Eleanor ;

Leyland-Jones, Brian ;

Bell, Richard ;

Dowsett, Mitch ;

Jackisch, Christian .

LANCET, 2017, 389 (10075) :1195-1205

[7]

Cataldo Alessandra, 2018, Oncotarget, V9, P27920, DOI 10.18632/oncotarget.24723

[8] Real-time quantification of microRNAs by stem-loop RT-PCR [J].

Chen, CF ;

Ridzon, DA ;

Broomer, AJ ;

Zhou, ZH ;

Lee, DH ;

Nguyen, JT ;

Barbisin, M ;

Xu, NL ;

Mahuvakar, VR ;

Andersen, MR ;

Lao, KQ ;

Livak, KJ ;

Guegler, KJ .

NUCLEIC ACIDS RESEARCH, 2005, 33 (20) :e179.1-e179.9

[9] Population-based Estimate of the Prevalence of HER-2 Positive Breast Cancer Tumors for Early Stage Patients in the US [J].

Cronin, Kathleen A. ;

Harlan, Linda C. ;

Dodd, Kevin W. ;

Abrams, Jeffrey S. ;

Ballard-Barbash, Rachel .

CANCER INVESTIGATION, 2010, 28 (09) :963-968

[10] The colorectal microRNAome [J].

Cummins, JM ;

He, YP ;

Leary, RJ ;

Pagliarini, R ;

Diaz, LA ;

Sjoblom, T ;

Barad, O ;

Bentwich, Z ;

Szafranska, AE ;

Labourier, E ;

Raymond, CK ;

Roberts, BS ;

Juhl, H ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (10) :3687-3692

← 1 2 3 4 5 6 7 8 9 10 →