The Role of Plasminogen Activator Inhibitor-1 and Angiotensin-Converting Enzyme Gene Polymorphisms in Bronchopulmonary Dysplasia

被引:8
作者
Ince, Deniz Anuk [1 ]
Atac, Fatma Belgin [2 ]
Ozkiraz, Servet [1 ]
Dilmen, Ugur [3 ]
Gulcan, Hande [1 ]
Tarcan, Aylin [1 ]
Ozbek, Namik [1 ]
机构
[1] Baskent Univ, Sch Med, Dept Pediat, TR-06490 Ankara, Turkey
[2] Baskent Univ, Sch Med, Dept Med Biol & Genet, TR-06490 Ankara, Turkey
[3] Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Dept Pediat, Ankara, Turkey
关键词
RESPIRATORY-DISTRESS-SYNDROME; BIRTH-WEIGHT INFANTS; INSERTION DELETION POLYMORPHISM; PRETERM INFANTS; 4G/5G POLYMORPHISM; EXPRESSION; FIBROSIS; CELLS; SUSCEPTIBILITY; COAGULATION;
D O I
10.1089/gtmb.2010.0072
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Bronchopulmonary dysplasia (BPD) is a multifactorial disease of preterm infants that is characterized by airway injury, inflammation, and parencymal remodeling. Activation of the coagulation cascade leads to intraalveolar fibrin deposition in many inflammatory pulmonary disorders. Increased fibrin formation or decreased fibrinolysis may cause extravascular fibrin deposition. Extravascular fibrin deposits in septae and alveoli due to the altered fibrin turnover are the pathological hallmarks of BPD, which strongly indicate the importance of the imbalance in the competing activities of coagulation and fibrinolysis. Objective: We investigated the predictive value of variations in plasminogen activator inhibitor-1 (PAI-1) and angiotensin-converting enzyme (ACE) genes as molecular determinants for BPD in neonates. Methods: The study group comprised 98 preterm infants with BPD and a control group including 94 preterm infants without BPD. Restriction fragment size analyses were performed by visualizing digested polymerase chain reaction products for ACE and PAI-1 genotypes. Results: No significant associations were found between ACE, PAI-1 gene polymorphisms, and BPD phenotype in our population. Conclusions: The two gene polymorphisms (PAI-1 and ACE) had no role in the development of BPD in our study. Further studies with other genes are required for the identification of molecular predisposing factors for BPD that may help in the development of new treatments.
引用
收藏
页码:643 / 647
页数:5
相关论文
共 41 条
[1]   The TNF-α-308, MCP-1-2518 and TGF-β1+915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants [J].
Adcock, K ;
Hedberg, C ;
Loggins, J ;
Kruger, TE ;
Baier, RJ .
GENES AND IMMUNITY, 2003, 4 (06) :420-426
[2]   Angiotensin-converting enzyme genotype is a predictive factor in the peak panel-reactive antibody response [J].
Akçay, A ;
Özdemir, FN ;
Ataç, FB ;
Sezer, S ;
Verdi, H ;
Arat, Z ;
Haberal, M .
TRANSPLANTATION PROCEEDINGS, 2004, 36 (01) :35-37
[3]  
Akinnusi Morohunfolu E., 2007, Inflammation & Allergy Drug Targets, V6, P201
[4]   Lack of Association Between FXIII-Val34Leu, FVII-323 del/ins, and Transforming Growth Factor β1 (915G/T) Gene Polymorphisms and Bronchopulmonary Dysplasia: A Single-Center Study [J].
Atac, Fatma Belgin ;
Ince, Deniz Anuk ;
Verdi, Hasibe ;
Gokmen, Zeynel ;
Yazici, Ayse Canan ;
Gulcan, Hande ;
Tarcan, Aylin ;
Taneri, Ayse ;
Sezgin, Ezgi ;
Ozbek, Namik .
DNA AND CELL BIOLOGY, 2010, 29 (01) :13-18
[5]   Definitions and diagnostic criteria for bronchopulmonary dysplasia [J].
Bancalari, Eduardo ;
Claure, Nelson .
SEMINARS IN PERINATOLOGY, 2006, 30 (04) :164-170
[6]  
Bancalari Eduardo, 2003, Semin Neonatol, V8, P63, DOI 10.1016/S1084-2756(02)00192-6
[7]   Familial and genetic susceptibility to major neonatal morbidities in preterm twins [J].
Bhandari, Vineet ;
Bizzarro, Matthew J. ;
Shetty, Anupama ;
Zhong, Xiaoyun ;
Page, Grier P. ;
Zhang, Heping ;
Ment, Laura R. ;
Gruen, Jeffrey R. .
PEDIATRICS, 2006, 117 (06) :1901-1906
[8]   Dysplasia:: A review [J].
Bokodi, Geza ;
Treszl, Andras ;
Kovacs, Lajos ;
Tulassay, Tivadar ;
Vasarhelyi, Barna .
PEDIATRIC PULMONOLOGY, 2007, 42 (10) :952-961
[9]   High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndrome [J].
Cederqvist, K ;
Sirén, V ;
Petäjä, J ;
Vaheri, A ;
Haglund, C ;
Andersson, S .
PEDIATRICS, 2006, 117 (04) :1226-1234
[10]   Prevalence of Thrombophilic Mutations and ACE I/D Polymorphism in Turkish Ischemic Stroke Patients [J].
Celiker, Gulay ;
Can, Ufuk ;
Verdi, Hasibe ;
Yazici, Ayse Canan ;
Ozbek, Namik ;
Atac, Fatma Belgin .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2009, 15 (04) :415-420