Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii

被引：0
|
作者：
Takeshima, Kinuko [1 ,2 ]
Sato, Kazuki [1 ]
Nabekura, Tsukasa [1 ,4 ]
Nagamune, Kisaburo [3 ,6 ]
Hamada, Hiromi [2 ]
Yoshikawa, Hiroyuki [2 ]
Shibuya, Akira [1 ,4 ,5 ]
Shibuya, Kazuko [1 ]
机构：
[1] Univ Tsukuba, Fac Med, Dept Immunol, Tsukuba, Ibaraki 3058575, Japan
[2] Univ Tsukuba, Fac Med, Tsukuba, Ibaraki 3058575, Japan
[3] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058575, Japan
[4] Univ Tsukuba, Life Sci Ctr, Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058575, Japan
[5] Univ Tsukuba, Core Res Evolut Sci & Technol, Japan Sci & Technol Agcy, Tsukuba, Ibaraki 3058575, Japan
[6] Natl Inst Infect Dis, Dept Parasitol, Tokyo, Japan
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2015年 / 59卷 / 02期
关键词：
CD11b(+) Gr-1(+) cell; flow cytometry analysis; placenta; INFLAMMATORY MONOCYTES; RECRUITMENT; NEUTROPHILS; RESISTANCE; GAMMA;
D O I：
10.1111/1348-0421.12225
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toxoplasma gondii is an obligate intracellular protozoan pathogen that can cross the placenta, resulting in congenital toxoplasmosis with severe fetal brain abnormalities. The molecular mechanisms of immune responses against T. gondii infection in the placenta have largely remained unclear. An analytical method for characterizing phenotypes of immune cells in the placenta by flow cytometry was established and it was found that numbers of CD11b(+) Gr-1(+) cells in the placenta increased significantly after T. gondii infection. These results suggest that innate immune responses play an important role in immunity against T. gondii infection via the feto-maternal interface.
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收藏
页码：95 / 98
页数：4
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