An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria

被引：39

作者：

Zhao, Xiongfei ^{[1
]}

Zheng, Weidong ^{[2
]}

Qin, Tianyi ^{[1
]}

Du, Xinfeng ^{[3
]}

Lei, Yanmei ^{[2
]}

Lv, Taoyuze ^{[1
]}

Zhou, Mei ^{[1
]}

Xu, Zhongyong ^{[1
]}

Wang, Lei ^{[1
]}

Liu, Bin ^{[1
]}

Peng, Xiaojun ^{[1
,4
]}

机构：

[1] Coll Mat Sci & Engn, Guangdong Res Ctr Interfacial Engn Funct Mat, Shenzhen, Peoples R China

[2] Shenzhen Univ, Shenzhen Univ Gen Hosp, Dept Lab Med, Shenzhen 518060, Peoples R China

[3] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

[4] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2022年 / 351卷

基金：

中国国家自然科学基金;

关键词：

Fluorescent probes; Albumin; Albuminuria; Point-of-care; Transition dipole moment; Anti-interference; HUMAN SERUM-ALBUMIN; CHRONIC KIDNEY-DISEASE; COLOR-DIFFERENCE; QUANTIFICATION; RECOGNITION; SENSOR; URINE;

D O I：

10.1016/j.snb.2021.130980

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Determination of albuminuria at the point-of-care can provide an early diagnosis and monitor the quality management of numerous diseases. Yet for most fluorescent probes, the detection accuracy is not reliable, since urine itself exhibits very strong endogenous fluorescence causing a considerable interference on response signal. We herein report a novel fluorescent probe DNC with an enhanced environmental sensitivity and red-shifted wavelength (> 600 nm) by enlarging its transition dipole moment. The DNC could selectively bind with drug sites of albumin, causing a significant fluorescence enhancement without the interference from urinary fluorescence. Based on this sensing approach, albuminuria could be directly diagnosed at the point-of-care by using a simple homemade test system (even by naked eyes) without complicate pretreatment of urine.

引用

页数：7

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