Covalent modifications of histones during development and disease pathogenesis

被引：521
作者：
Bhaumik, Sukesh R.
Smith, Edwin
Shilatifard, Ali [1 ]
机构：
[1] So Illinois Univ, Sch Med, Dept Biochem & Mol Biol, Carbondale, IL 62901 USA
[2] Stowers Inst Med Res, Kansas City, MO 64110 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 11期
关键词：
D O I：
10.1038/nsmb1337
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.
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收藏
页码：1008 / 1016
页数：9
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