Effect of Statins on Lung Cancer Molecular Pathways: A Possible Therapeutic Role

被引：21

作者：

Marciano, Gianmarco ^{[1
]}

Palleria, Caterina ^{[2
]}

Casarella, Alessandro ^{[1
]}

Rania, Vincenzo ^{[1
]}

Basile, Emanuele ^{[1
]}

Catarisano, Luca ^{[1
]}

Vocca, Cristina ^{[1
]}

Bianco, Luigi ^{[2
]}

Pelaia, Corrado ^{[2
]}

Cione, Erika ^{[3
]}

D'Agostino, Bruno ^{[4
]}

Citraro, Rita ^{[1
,2
,5
]}

De Sarro, Giovambattista ^{[1
,2
,5
]}

Gallelli, Luca ^{[1
,2
,5
]}

机构：

[1] Univ Catanzaro, Sch Med, Dept Hlth Sci, I-88100 Catanzaro, Italy

[2] Mater Domini Hosp, Operat Unit Clin Pharmacol & Pharmacovigilanze, I-88100 Catanzaro, Italy

[3] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[4] Univ Campania Luigi Vanvitelli, Sch Med, Dept Expt Med L Donatelli, Sect Pharmacol, I-80100 Naples, Italy

[5] Univ Catanzaro, Sch Med, Dept Hlth Sci, Res Ctr FAS UMG, I-88100 Catanzaro, Italy

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 05期

关键词：

statin; lung cancer; treatment; targets; PREVIOUSLY TREATED PATIENTS; EMBRYONIC STEM-CELLS; RANDOMIZED PHASE-II; NF-KAPPA-B; LIPID-METABOLISM; IN-VITRO; MATRIX METALLOPROTEINASES; TUMOR PROGRESSION; PLUS SIMVASTATIN; EXPRESSION;

D O I：

10.3390/ph15050589

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lung cancer is a common neoplasm, usually treated through chemotherapy, radiotherapy and/or surgery. Both clinical and experimental studies on cancer cells suggest that some drugs (e.g., statins) have the potential to improve the prognosis of cancer. In fact, statins blocking the enzyme "hydroxy-3-methylglutaryl-coenzyme A reductase" exert pleiotropic effects on different genes involved in the pathogenesis of lung cancer. In this narrative review, we presented the experimental and clinical studies that evaluated the effects of statins on lung cancer and described data on the effectiveness and safety of these compounds. We also evaluated gender differences in the treatment of lung cancer to understand the possibility of personalized therapy based on the modulation of the mevalonate pathway. In conclusion, according to the literature data, statins exert multiple effects on lung cancer cells, even if the evidence for their use in clinical practice is lacking.

引用

页数：27

共 131 条

[1] Response by sex to statin plus ezetimibe or statin monotherapy: A pooled analysis of 22,231 hyperlipidemic patients [J].

Abramson, Beth L. ;

Benlian, Pascale ;

Hanson, Mary E. ;

Lin, Jianxin ;

Shah, Arvind ;

Tershakovec, Andrew M. .

LIPIDS IN HEALTH AND DISEASE, 2011, 10

[2] Blood-based detection of lung cancer using cysteine-rich angiogenic inducer 61 (CYR61) as a circulating protein biomarker: a pilot study [J].

Ackar, Lucija ;

Casjens, Swaantje ;

Andreas, Antje ;

Raiko, Irina ;

Bruening, Thomas ;

Geffken, Maria ;

Peine, Sven ;

Kollmeier, Jens ;

Johnen, Georg ;

Bartkowiak, Kai ;

Weber, Daniel Gilbert ;

Pantel, Klaus .

MOLECULAR ONCOLOGY, 2021, 15 (11) :2877-2890

[3] CAV1-GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer [J].

Ali, Azhar ;

Levantini, Elena ;

Fhu, Chee Wai ;

Teo, Jun Ting ;

Clohessy, John G. ;

Goggi, Julian L. ;

Wu, Chan-shuo ;

Chen, Leilei ;

Chin, Tan Min ;

Tenen, Daniel G. .

THERANOSTICS, 2019, 9 (21) :6157-6174

[4] Repeated observation of immune gene sets enrichment in women with non-small cell lung cancer [J].

Araujo, Jhajaira M. ;

Prado, Alexandra ;

Cardenas, Nadezhda K. ;

Zaharia, Mayer ;

Dyer, Richard ;

Doimi, Franco ;

Bravo, Leny ;

Pinillos, Luis ;

Morante, Zaida ;

Aguilar, Alfredo ;

Mas, Luis A. ;

Gomez, Henry L. ;

Vallejos, Carlos S. ;

Rolfo, Christian ;

Pinto, Joseph A. .

ONCOTARGET, 2016, 7 (15) :20282-20292

[5] Age and gender bias in statin trials [J].

Bandyopadhyay, S ;

Bayer, AJ ;

O'Mahony, MS .

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2001, 94 (03) :127-132

[6] Gender related differences in treatment and response to statins in primary and secondary cardiovascular prevention: The never-ending debate [J].

Cangemi, Roberto ;

Romiti, Giulio Francesco ;

Campolongo, Giuseppe ;

Ruscio, Eleonora ;

Sciomer, Susanna ;

Gianfrilli, Daniele ;

Raparelli, Valeria .

PHARMACOLOGICAL RESEARCH, 2017, 117 :148-155

[7] High-intensity statins are associated with improved clinical activity of PD-1 inhibitors in malignant pleural mesothelioma and advanced non-small cell lung cancer patients [J].

Cantini, Luca ;

Pecci, Federica ;

Hurkmans, Daan P. ;

Belderbos, Robert A. ;

Lanese, Andrea ;

Copparoni, Cecilia ;

Aerts, Sophie ;

Cornelissen, Robin ;

Dumoulin, Daphne W. ;

Fiordoliva, Ilaria ;

Rinaldi, Silvia ;

Aerts, Joachim G. J. V. ;

Berardi, Rossana .

EUROPEAN JOURNAL OF CANCER, 2021, 144 :41-48

[8] MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase [J].

Cao, Zhongwei ;

Fan-Minogue, Hua ;

Bellovin, David I. ;

Yevtodiyenko, Aleksey ;

Arzeno, Julia ;

Yang, Qiwei ;

Gambhir, Sanjiv Sam ;

Felsher, Dean W. .

CANCER RESEARCH, 2011, 71 (06) :2286-2297

[9] Statin Use and Survival from Lung Cancer: A Population-Based Cohort Study [J].

Cardwell, Chris R. ;

Mc Menamin, Una ;

Hughes, Carmel M. ;

Murray, Liam J. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2015, 24 (05) :833-841

[10]

Caterina P, 2013, J RES MED SCI, V18, P600

← 1 2 3 4 5 6 7 8 9 10 →