Comparison of commercial and experimental porcine circovirus type 2 (PCV2) vaccines using a triple challenge with PCV2, porcine reproductive and respiratory syndrome virus (PRRSV), and porcine parvovirus (PPV)

被引：56

作者：

Shen, H. G. ^{[1
]}

Beach, N. M. ^{[2
]}

Huang, Y. W. ^{[2
]}

Halbur, P. G. ^{[1
]}

Meng, X. J. ^{[2
]}

Opriessnig, T. ^{[1
]}

机构：

[1] Iowa State Univ, Coll Vet Med, Dept Vet Diagnost & Prod Anim Med, Ames, IA 50011 USA

[2] Virginia Polytech Inst & State Univ, Coll Vet Med, Ctr Mol Med & Infect Dis, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA

来源：

VACCINE | 2010年 / 28卷 / 37期

关键词：

Porcine circovirus type 2 (PCV2); Coinfection; Vaccine efficacy; PRRSV; PPV; MULTISYSTEMIC WASTING SYNDROME; CONVENTIONAL PIGS; CAPSID PROTEIN; SYNDROME PMWS; EXPERIMENTAL-INFECTION; PROTECTIVE IMMUNITY; NONPATHOGENIC PCV1; IN-VITRO; VACCINATION; DISEASE;

D O I：

10.1016/j.vaccine.2010.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The efficacies of commercial porcine circovirus type 2 (PCV2) vaccines and a live PCV1-2a chimeric vaccine were compared in conventional, PCV2-positive piglets using a PCV2-porcine reproductive and respiratory syndrome virus (PRRSV)-porcine parvovirus (PPV) coinfection challenge model. Seventy-three, 2-week-old pigs were randomized into seven groups including five vaccinated and two control groups. Pigs in the vaccinated groups were vaccinated at 3 weeks (one dose) or at 3 and 6 weeks (two dose) of age. All vaccine regimens tested were effective in reducing naturally occurring PCV2 viremia at 16 weeks of age and after PCV2 challenge, demonstrating the capability of the products to induce a lasting protective immunity despite the presence of PCV2 viremia at the time of vaccination. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5960 / 5966

页数：7

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