Recurrent tuberculosis from 1992 to 2004 in a metropolitan area

被引:32
作者
Cacho, J.
Perez Meixeira, A.
Cano, I.
Soria, T.
Martos, A. Ramos
Sanchez Concheiro, M.
Samper, S.
Gavin, P.
Martin, C.
机构
[1] Univ Hosp Getafe, Dept Microbiol, Madrid 28905, Spain
[2] Univ Hosp Getafe, Dept Pulmonol, Madrid, Spain
[3] Autonomous Community Madrid, Dept Publ Hlth, Madrid, Spain
[4] Univ Saragossa, Mycobacteria Genet Grp & CIBER Resp Dis, Zaragoza, Spain
关键词
epidemiology; recurrence; re-infection; relapse; restriction fragment length polymorphism; tuberculosis;
D O I
10.1183/09031936.00005107
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The proportion of recurrent tuberculosis (TB) cases caused by re-infection has varied widely in previous studies. The aim of the present study was to determine the relative frequency of relapse and exogenous re-infection in patients with second episodes of TB, using DNA fingerprinting. A population-based retrospective longitudinal descriptive study was conducted in Madrid (Spain) during 1992-2004. The study consisted of 645 patients with culture-confirmed TB. Of these, 20 (3.1 %) were retained because they presented with a second isolate of Mycobacterium tuberculosis. Finally, 12 of these cases were excluded because they did not complete the full treatment prescribed. All strains were typed by restriction fragment length polymorphism analysis and some by mycobacterial interspersed repetitive unit-variable number of tandem repeats analysis. The patients with recurrent TB were compared with those without recurrent TB. For seven out of the eight patients, the restriction fragment length polymorphism patterns of the Mycobacterium tuberculosis strains from the episodes of recurrent disease showed identical initial and final genotypes, indicating relapse; the remaining recurrent case showed different genotypes, suggesting exogenous re-infection. Re-infection is possible among people in developed countries, but the rates are lower than those occurring in high-risk areas. The risk factors for recurrent tuberculosis should be taken into account in the follow-up of treatment and tuberculosis control strategies.
引用
收藏
页码:333 / 337
页数:5
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