Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives

被引：4

作者：

Anderson, Albert M. ^{[1
]}

Schein, Theresa N. ^{[2
]}

Kalapila, Aley ^{[1
]}

Lai, Lillin ^{[1
]}

Waldrop-Valverde, Drenna ^{[3
]}

Moore, Raeanne C. ^{[4
]}

Franklin, Donald ^{[4
]}

Letendre, Scott L. ^{[4
,5
]}

Barnum, Scott R. ^{[2
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA

[2] Univ Alabama Birmingham, Birmingham Sch Med, Dept Microbiol, Birmingham, AL USA

[3] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA

[4] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 311卷

关键词：

Human immunodeficiency virus; Acquired immunodeficiency syndrome; Neurocognitive disorder; Complement; Membrane attack complex; NEUROCOGNITIVE DISORDERS; ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; SYSTEM; MARKERS; BRAIN; CELLS; AGE;

D O I：

10.1016/j.jneuroim.2017.07.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The soluble membrane attack complex (sMAC) represents the terminal product of the complement cascade. We enrolled 47 HIV + adults (12 of whom underwent a second visit at least 24 weeks after starting therapy) as well as 11 HIV negative controls. At baseline, cerebrospinal fluid (CSF) sMAC was detectable in 27.7% of HIV + individuals. CSF sMAC correlated with CSF HIV RNA levels and was more likely to be detectable in HIV + individuals on CART compared to HIV negative controls. In HIV + participants, there were negative association trends between sMAC and neurocognitive performance but these did not reach statistical significance.

引用

页码：35 / 39

页数：5

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