The use of cyclodextrin-based LC stationary phases for the separation of chiral dihydrobenzofuran derivatives

被引：19

作者：

Soukup, RJ ^{[1
]}

Rozhkov, RV ^{[1
]}

Larock, RC ^{[1
]}

Armstrong, DW ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50010 USA

来源：

CHROMATOGRAPHIA | 2005年 / 61卷 / 5-6期

基金：

美国国家卫生研究院;

关键词：

column liquid chromatography; beta-cyclodextrin chiral stationary phases; enantioseparations; dihydrobenzofurans;

D O I：

10.1365/s10337-005-0519-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric separation of 12 chiral dihydrobenzofurans is reported on derivatized beta-cyclodextrin stationary phases using high performance liquid chromatography. The hydroxypropyl beta-cyclodextrin chiral stationary phase (CSP) with acetonitrile/water mobile phases was the most effective combination as it baseline separated 9 of the 12 compounds. The acetyl beta-cyclodextrin and 2,3-dimethyl beta-cyclodextrin CSPs were also effective in the reverse phase mode. The native beta-cyclodextrin was far less effective than the non-aromatic derivatized CSPs. The aromatic functionalized CSPs showed no selectivity in the normal phase mode. Structural characteristics, such as substituent polarity and ring location, were important in the observed enantioselectivity.

引用

页码：219 / 224

页数：6

共 21 条

[1]

[Anonymous], 1992, Chirality, V4, P338

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