Disability and health-related quality of life in Chinese patients with rheumatoid arthritis: A cross-sectional study

被引：28

作者：

Zhou, Yunshan ^{[1
]}

Wang, Xiuru ^{[2
]}

An, Yuan ^{[1
]}

Zhang, Xiaoying ^{[1
]}

Han, Shuling ^{[3
]}

Li, Xiaofeng ^{[4
]}

Wang, Lizhi ^{[4
]}

Wang, Caihong ^{[4
]}

Wang, Yongfu ^{[5
]}

Yang, Rong ^{[5
]}

Wang, Guochun ^{[6
]}

Lu, Xin ^{[6
]}

Zhu, Ping ^{[7
]}

Chen, Lina ^{[7
]}

Liu, Jinting ^{[8
]}

Jin, Hongtao ^{[8
]}

Liu, Xiangyuan ^{[9
]}

Sun, Lin ^{[9
]}

Wei, Ping ^{[10
]}

Wang, Junxiang ^{[10
]}

Chen, Haiying ^{[10
]}

Cui, Liufu ^{[11
]}

Shu, Rong ^{[11
]}

Zhang, Zhuoli ^{[12
]}

Li, Guangtao ^{[12
]}

Li, Zhenbin ^{[13
]}

Yang, Jing ^{[13
]}

Li, Junfang ^{[14
]}

Jia, Bin ^{[14
]}

Zhang, Fengxiao ^{[15
]}

Tao, Jiemei ^{[15
]}

Lin, Jinying ^{[16
]}

Wei, Qiumei ^{[16
]}

Liu, Xiaomin ^{[17
]}

Ke, Dan ^{[17
]}

Hu, Shaoxian ^{[18
]}

Ye, Cong ^{[18
]}

Yang, Xiuyan ^{[19
]}

Li, Hao ^{[19
]}

Huang, Cibo ^{[20
]}

Gao, Ming ^{[20
]}

Li, Xingfu ^{[21
]}

Song, Lijun ^{[21
]}

Wang, Yi ^{[22
]}

Wang, Xiaoyuan ^{[22
]}

Mu, Rong ^{[1
]}

Su, Yin ^{[1
]}

Li, Zhanguo ^{[1
]}

机构：

[1] Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[2] Peking Univ, Shougang Hosp, Duoding St Community Hlth Ctr, Beijing, Peoples R China

[3] Peking Univ, Shougang Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[4] Shanxi Med Univ, Hosp 2, Dept Rheumatol & Immunol, Taiyuan, Shanxi, Peoples R China

[5] Baotou Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Baotou, Peoples R China

[6] China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China

[7] Fourth Mil Med Univ, Xijing Hosp, Dept Clin Immunol, Xian, Shaanxi, Peoples R China

[8] Hebei Med Univ, Hosp 2, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China

[9] Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing, Peoples R China

[10] Hebei Med Univ, Hosp 3, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China

[11] North China Coal Med Univ, Affiliated Kailuan Hosp, Dept Rheumatol & Immunol, Tangshan, Peoples R China

[12] Peking Univ, Hosp 1, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China

[13] PLA, Bethune Int Peace Hosp, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China

[14] Handan Cent Hosp, Dept Rheumatol & Immunol, Handan, Peoples R China

[15] Peoples Hosp Hebei Prov, Dept Rheumatol & Immunol, Shijiazhuang, Hebei, Peoples R China

[16] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Rheumatol, Nanning, Peoples R China

[17] Beijing Shunyi Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[18] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Rheumatol, Wuhan, Hubei, Peoples R China

[19] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rheumatol, Guangzhou, Guangdong, Peoples R China

[20] Beijing Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[21] Shandong Univ, Qilu Hosp, Dept Rheumatol, Jinan, Shandong, Peoples R China

[22] Lanzhou Univ, Hosp 2, Dept Rheumatol, Lanzhou, Gansu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2018年 / 21卷 / 09期

关键词：

disability evaluation; patient reported outcome measures; quality of life; rheumatoid arthritis; FUNCTIONAL-DISABILITY; ASSESSMENT QUESTIONNAIRE; SOCIETAL COSTS; SF-36; SENSITIVITY; POPULATION; PREDICTORS; DISEASE; IMPACT;

D O I：

10.1111/1756-185X.13345

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: The objective of this study was to evaluate the impact of rheumatoid arthritis (RA) on physical function and health-related quality of life (HRQoL) in China. Method: A cross-section survey was conducted in 21 general hospitals in China. Eight hundred and seven patients were recruited. Data on demographics, clinical data, physical function (Stanford Health Assessment Questionnaire Disability Index, HAQ-DI) and HRQoL (Study Short Form 36 Health Survey, SF-36) were collected on site. Results: In our cohort, physical function was impaired in 77.6% of patients (HAQ-DI >0). The median (interquartile range, IQR) of HAQ-DI was 0.750 (0.125, 1.500). Rated by HAQ-DI 0-1, >1-2, and >2-3, percentage of patients with mild, moderate and severe disability was 61.0%, 25.4%, and 13.6%, respectively. Older age, long disease duration, presence of extra-articular manifestations, tender joint count (TJC), overall status (assessed by patient Global Visual Analogue Scale [G-VAS] and physician G-VAS) and lacking disease-modifying anti-rheumatic drugs were identified as predictive factors for worse physical function (P < .05). The composite scores of SF-36 in the observed patients were: physical component summary 40.4 (IQR 27.4, 60.3), and mental component summary 49.0 (IQR 33.6, 70.9). Impaired physical health may be predicted by low income, presence of extra-articular manifestations, TJC, patient G-VAS and high HAQ-DI. Predictors for suboptimal mental health were low income, physical labor, married status, increased swollen joint count (SJC), physician G-VAS and high HAQ-DI. Conclusion: Rheumatoid arthritis has profound effects on physical function and HRQoL in Chinese patients. Patients with identified predictive factors for poor outcome should be closely monitored.

引用

页码：1709 / 1715

页数：7

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