Organocatalyzed Intramolecular Carbonyl-Ene Reactions

被引：3

作者：

Dahlmann, Heidi A. ^{[1
]}

McKinney, Amanda J. ^{[1
]}

Santos, Maria P. ^{[1
]}

Davis, Lindsey O. ^{[1
]}

机构：

[1] Berry Coll, Dept Chem & Biochem, POB 495016, Mt Berry, GA 30149 USA

来源：

MOLECULES | 2016年 / 21卷 / 06期

关键词：

organocatalysis; carbonyl-ene; phosphoric acid; N-triflylphosphoramide; BOND DONORS; CYCLIZATION; CATALYSTS; PIPERIDINES; ACIDS;

D O I：

10.3390/molecules21060713

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An organocatalyzed intramolecular carbonyl-ene reaction was developed to produce carbocyclic and heterocyclic 5- and 6-membered rings from a citronellal-derived trifluoroketone and a variety of aldehydes. A phosphoramide derivative was found to promote the cyclization of the trifluoroketone, whereas a less acidic phosphoric acid proved to be a superior catalyst for the aldehyde substrates.

引用

页数：7

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