Epidemiological characteristics and influential factors of hand, foot, and mouth disease reinfection in Wuxi, China, 2008-2016

被引:18
作者
Shi, Chao [1 ]
Liu, Juan [1 ]
Shi, Ping [1 ]
Ji, Hong [2 ]
Shen, Yuan [1 ]
Qian, Yan-Hua [1 ]
机构
[1] Wuxi Ctr Dis Control & Prevent, Wuxi 214023, Jiangsu, Peoples R China
[2] Jiangsu Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Hand; Foot; And mouth disease; Reinfection; Epidemiology; EVOLUTION; OUTBREAK; CHILDREN;
D O I
10.1186/s12879-018-3385-1
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Hand, foot, and mouth disease (HFMD) is a viral disease caused by human enteroviruses. Although HFMD reinfection is common, studies investigating this phenomenon are insufficient. Methods: The present study focused on HFMD reinfection in Wuxi from 2008 to 2016 using surveillance system data. Results: Of 107,677 cases included in the study, 6470 cases were classified as reinfections. The overall reinfection rate was 6.01% (6.37% male and 5.48% female patients), which decreased with increasing age (chi(2) = 1125.477, p < 0.001). The rate was 6.17 and 5.79% in urban and rural areas, respectively, and 7.83 and 5.98% of the cases were severe and mild, respectively. Multivariate logistic regression analysis showed that male sex, younger age, residence in an urban area, and severe disease were risk factors for HFMD reinfection. The case-severity rate in secondary infection cases was lower than that in non-reinfection cases (odds ratio 0.675, 95% confidence interval 0.526-0.866). Conclusions: Boys younger than 4 years of age living in urban areas were more prone to reinfection. Specific health education and intervention should be developed to protect these susceptible populations.
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页数:7
相关论文
共 23 条
  • [1] Ang LW, 2009, ANN ACAD MED SINGAP, V38, P106
  • [2] Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998
    Brown, BA
    Oberste, MS
    Alexander, JP
    Kennett, ML
    Pallansch, MA
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (12) : 9969 - 9975
  • [3] Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: Clinical and pathological characteristics of the disease
    Chan, LG
    Parashar, UD
    Lye, MS
    Ong, FGL
    Zaki, SR
    Alexander, JP
    Ho, KK
    Han, LL
    Pallansch, MA
    Suleiman, AB
    Jegathesan, M
    Anderson, LJ
    [J]. CLINICAL INFECTIOUS DISEASES, 2000, 31 (03) : 678 - 683
  • [4] Chen C, 2012, CHINESE J TROPICAL M, V12, P934
  • [5] Epidemiological characteristics and influential factors of hand, foot and mouth disease (HFMD) reinfection in children in Anhui province
    Chen, G. -P.
    Wu, J. -B.
    Wang, J. -J.
    Pan, H. -F.
    Zhang, J.
    Shi, Y. -L.
    Cao, C.
    Li, F. -R.
    Fan, Y. -G.
    Meng, F. -Y.
    Ye, D. -Q.
    [J]. EPIDEMIOLOGY AND INFECTION, 2016, 144 (01) : 153 - 160
  • [6] Short Term Effects of Weather on Hand, Foot and Mouth Disease
    Hii, Yien Ling
    Rocklov, Joacim
    Ng, Nawi
    [J]. PLOS ONE, 2011, 6 (02):
  • [7] An epidemic of enterovirus 71 infection in Taiwan
    Ho, MT
    Chen, ER
    Hsu, KH
    Twu, SJ
    Chen, KT
    Tsai, SF
    Wang, JR
    Shih, SR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (13) : 929 - 935
  • [8] Cross-reactive Neutralizing Antibody Responses to Enterovirus 71 Infections in Young Children: Implications for Vaccine Development
    Huang, Mei-Liang
    Chiang, Pai-Shan
    Chia, Min-Yuan
    Luo, Shu-Ting
    Chang, Luan-Yin
    Lin, Tzou-Yien
    Ho, Mei-Shang
    Lee, Min-Shi
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (02):
  • [9] Seroprevalence of enterovirus 71 and no evidence of crossprotection of enterovirus 71 antibody against the other enteroviruses in kindergarten children in Taipei city
    Huang, Wen-Chan
    Huang, Li-Min
    Kao, Chuan-Liang
    Lu, Chun-Yi
    Shao, Pei-Lan
    Cheng, Ai-Ling
    Fan, Tsui-Yien
    Chi, Hsin
    Chang, Luan-Yin
    [J]. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2012, 45 (02) : 96 - 101
  • [10] Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China
    Ji, Hong
    Li, Liang
    Liu, YanMing
    Ge, HengMing
    Wang, XuShan
    Hu, JianLi
    Wu, Bin
    Fu, JianGuang
    Zhang, ZhenYu
    Chen, XiaoQin
    Zhang, MingLei
    Ding, Qiang
    Xu, WenBo
    Tang, FenYang
    Zhou, MingHao
    Wang, Hua
    Zhu, FengCai
    [J]. VIROLOGY JOURNAL, 2012, 9