Diffuse Large B-Cell Lymphoma and High-Grade B-Cell Lymphoma Genetic Classification and Its Implications for Prognosis and Treatment

被引：9

作者：

Crombie, Jennifer L. ^{[1
]}

Armand, Philippe ^{[1
]}

机构：

[1] Harvard Med Sch, Dana Farber Canc Inst, Med Oncol, 450 Brookline Ave, Boston, MA 02215 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2020年 / 29卷 / 01期

关键词：

Diffuse large B-cell lymphoma; DLBCL; Cell of origin; Genomic classifications; Targeted therapy; Precision medicine; DOUBLE-HIT LYMPHOMA; R-CHOP; SURVIVAL; CHEMOTHERAPY; IMPACT; TRANSPLANTATION; BORTEZOMIB; EXPRESSER; SUBTYPES; OUTCOMES;

D O I：

10.1016/j.soc.2019.08.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non Hodgkin lymphoma, is characterized by both clinical and molecular heterogeneity. Despite efforts to tailor therapy for individual patients, treatment remains uniform and a subset of patients have poor outcomes. The past decade has witnessed a dramatic expansion of our understanding of the genomic underpinnings of this disease, especially with the application of next-generation sequencing. In this review, the authors highlight the current genomic landscape of DLBCL and how this information provides a potential molecular framework for precision medicine-based strategies in this disease.

引用

页码：115 / +

页数：12

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