Cryo-thawed embryos obtained from conception cycles have double the implantation and pregnancy potential of those from unsuccessful cycles

被引:36
作者
El-Toukhy, T [1 ]
Khalaf, Y [1 ]
Al-Darazi, K [1 ]
O'Mahony, F [1 ]
Wharf, E [1 ]
Taylor, A [1 ]
Braude, P [1 ]
机构
[1] Guys & St Thomas Hosp NHS Trust, Assisted Concept Unit, London SE1 9RT, England
关键词
cryo-thawed cycle prognosis; embryo cryopreservation; IVF outcome;
D O I
10.1093/humrep/deg235
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: The purpose of this study was to evaluate the influence of fresh IVF/ICSI cycle outcome on the prognosis of the related frozen embryo replacement (FER) cycle. METHODS: 459 FER cycles, involving 2049 cleavage stage embryos with no or up to 10% fragmentation, were performed for which the outcome of the fresh cycle was recorded. The cycles were divided into two groups; group A included cycles in which cryopreserved embryos were obtained from fresh cycles in which conception occurred. Group B were cycles in which cryopreserved embryos originated from unsuccessful fresh cycles. RESULTS: Groups A and B were comparable with respect to mean (+/-SD) age at cryopreservation (33 +/- 3.9 versus 33.2 +/- 4 years, P not significant), mean number of oocytes retrieved and fertilized normally in the fresh cycle (11 +/- 5.2 versus 11.2+/- 4.8, P = not significant) and mean age at the cryo-thawed transfer (34.5 +/- 4.2 versus 33.9 +/- 4 years, P = not significant). No significant difference was found between the two groups with regard to mean number of embryos cryopreserved (6.5 +/- 3.9 versus 6.2 +/- 3.6) and subsequently thawed (4.5 +/- 2.5 versus 4.5 +/- 1.8) per cycle and number of cryo-thawed embryos transferred per cycle (2.0 +/- 0.7 versus 2.1 +/- 0.8). However, the implantation rate per transferred embryo in group A was double that in group B (23 versus 11.2%, P < 0.0001). Moreover, the clinical pregnancy and ongoing pregnancy rates per cycle were significantly higher in group A compared with group B (34.8 and 27.3% versus 15.6 and 13.1%, P < 0.0001 and P = 0.0003 respectively). The difference in FER cycle outcome could not be explained by confounding variables. CONCLUSIONS: After thawing, cryopreserved embryos originating from conception IVF/ICSI cycles achieve double the implantation and pregnancy rates of those obtained from unsuccessful cycles.
引用
收藏
页码:1313 / 1318
页数:6
相关论文
共 36 条
[1]  
ACOSTA AA, 1990, FERTIL STERIL, V53, P673
[2]   EARLY-PREGNANCY LOSS AND OBSTETRICAL RISK AFTER INVITRO FERTILIZATION AND EMBRYO REPLACEMENT [J].
BARLOW, P ;
LEJEUNE, B ;
PUISSANT, F ;
ENGLERT, Y ;
VANRYSSELBERGE, M ;
DEGUELDRE, M ;
VEKEMANS, M ;
LEROY, F .
HUMAN REPRODUCTION, 1988, 3 (05) :671-675
[3]   Early pregnancy loss in in vitro fertilization (IVF) is a positive predictor of subsequent IVF success [J].
Bates, GW ;
Ginsburg, ES .
FERTILITY AND STERILITY, 2002, 77 (02) :337-341
[4]   ESTIMATING SAMPLE SIZES FOR BINARY, ORDERED CATEGORICAL, AND CONTINUOUS OUTCOMES IN 2 GROUP COMPARISONS [J].
CAMPBELL, MJ ;
JULIOUS, SA ;
ALTMAN, DG .
BRITISH MEDICAL JOURNAL, 1995, 311 (7013) :1145-1148
[5]   Predictive value of the results of a first in-vitro fertilization cycle on the outcome of subsequent cycles [J].
Croucher, CA ;
Lass, A ;
Margara, R ;
Winston, RM .
HUMAN REPRODUCTION, 1998, 13 (02) :403-408
[6]   A quantitative analysis of the impact of cryopreservation on the implantation potential of human early cleavage stage embryos [J].
Edgar, DH ;
Bourne, H ;
Speirs, AL ;
McBain, JC .
HUMAN REPRODUCTION, 2000, 15 (01) :175-179
[7]   Sibling embryo blastocyst development correlates with the in vitro fertilization day 3 embryo transfer pregnancy rate in patients under age 40 [J].
Fisch, JD ;
Milki, AA ;
Behr, B .
FERTILITY AND STERILITY, 1999, 71 (04) :750-752
[8]  
FUGGER EF, 1988, FERTIL STERIL, V50, P273
[9]   Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial [J].
Gerris, J ;
De Neubourg, D ;
Mangelschots, K ;
Van Royen, E ;
Van de Meerssche, M ;
Valkenburg, M .
HUMAN REPRODUCTION, 1999, 14 (10) :2581-2587
[10]   Parameters guiding selection of best embryos for transfer after cryopreservation: a reappraisal [J].
Guerif, F ;
Bidault, R ;
Cadoret, V ;
Couet, ML ;
Lansac, J ;
Royere, D .
HUMAN REPRODUCTION, 2002, 17 (05) :1321-1326