The relationship between LAPTM4B polymorphisms and cancer risk in Chinese Han population: a meta-analysis

被引：9
作者：
Xia, Ling-Zi [1 ,2 ]
Yin, Zhi-Hua [1 ,2 ]
Ren, Yang-Wu [1 ,2 ]
Shen, Li [1 ,2 ]
Wu, Wei [1 ,2 ]
Li, Xue-Lian [1 ,2 ]
Guan, Peng [1 ,2 ]
Zhou, Bao-Sen [1 ,2 ]
机构：
[1] China Med Univ, Dept Epidemiol, Sch Publ Hlth, Shenyang, Peoples R China
[2] Univ Liaoning Prov, Key Lab Canc Etiol & Intervent, Shenyang, Peoples R China
来源：
SPRINGERPLUS | 2015年 / 4卷
基金：
中国国家自然科学基金;
关键词：
LAPTM4B; Polymorphism; Meta-analysis; Cancer risk; GENE POLYMORPHISM; HEPATOCELLULAR-CARCINOMA; TETRATRANSMEMBRANE PROTEIN; TRANSCRIPTION FACTORS; METABOLIC STRESS; AUTOPHAGY GENE; BREAST-CANCER; SUSCEPTIBILITY; TUMORIGENESIS; PROGNOSIS;
D O I：
10.1186/s40064-015-0941-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
LAPTM4B is a newly cloned gene that shows an active role in many solid tumors progression in substantial researches, mainly through the autophage function. Accumulated studies have been conducted to determine the association of LAPTM4B polymorphism with cancer risk. While the results are inconsistent, we conducted the meta-analysis to determine the strength of the relationship. Results showed that allele*2 carriers exhibited a significantly increased risk of cancer development with comparison to allele*1 homozygote ( for *1/2, OR = 1.55, 95% CI 1.367-1.758; for *2/2, OR = 2.093, 95% CI 1.666-2.629; for *1/2 + *2/2, OR = 1.806, 95% CI 1.527-2.137). We also observed a significant association between *2/2 homozygote and cancer risk with comparison to allele*1 containing genotypes ( OR = 1.714, 95% CI 1.408-2.088). Allele*2 is a risk factor for cancer risk ( OR = 1.487, 95% CI 1.339-1.651). Stratified analysis by tumor type exhibits the significant association of this genetic variants with various cancers. In conclusion, LAPTM4B polymorphism is associated with cancer risk and allele*2 is a risk factor.
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页数：8
相关论文
共 56 条
[1]   Autophagosome formation in mammalian cells [J].
Burman, Chloe ;
Ktistakis, Nicholas T. .
SEMINARS IN IMMUNOPATHOLOGY, 2010, 32 (04) :397-413
[2]   The phosphoinositide 3-kinase pathway [J].
Cantley, LC .
SCIENCE, 2002, 296 (5573) :1655-1657
[3]   Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers [J].
Cheng, X. -J. ;
Xu, W. ;
Zhang, Q. -Y. ;
Zhou, R. -L. .
ANNALS OF ONCOLOGY, 2008, 19 (03) :527-532
[4]   Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis [J].
Degenhardt, Kurt ;
Mathew, Robin ;
Beaudoin, Brian ;
Bray, Kevin ;
Anderson, Diana ;
Chen, Guanghua ;
Mukherjee, Chandreyee ;
Shi, Yufang ;
Gelinas, Celine ;
Fan, Yongjun ;
Nelson, Deirdre A. ;
Jin, Shengkan ;
White, Eileen .
CANCER CELL, 2006, 10 (01) :51-64
[5]   Lysosome-related organelles [J].
Dell'Angelica, EC ;
Mullins, C ;
Caplan, S ;
Bonifacino, JS .
FASEB JOURNAL, 2000, 14 (10) :1265-1278
[6]  
Deng Li-juan, 2005, Beijing Da Xue Xue Bao Yi Xue Ban, V37, P302
[7]   Life and death partners: apoptosis, autophagy and the cross-talk between them [J].
Eisenberg-Lerner, A. ;
Bialik, S. ;
Simon, H-U ;
Kimchi, A. .
CELL DEATH AND DIFFERENTIATION, 2009, 16 (07) :966-975
[8]   Association of LAPTM4B gene polymorphism with breast cancer susceptibility [J].
Fan, Meirong ;
Liu, Ye ;
Zhou, Rouli ;
Zhang, Qingyun .
CANCER EPIDEMIOLOGY, 2012, 36 (04) :364-368
[9]   Angiogenesis and apoptosis [J].
Folkman, J .
SEMINARS IN CANCER BIOLOGY, 2003, 13 (02) :159-167
[10]  
He Jing, 2003, Beijing Da Xue Xue Bao Yi Xue Ban, V35, P348
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