In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers

被引:9
|
作者
Lu, Yao [1 ,2 ]
Landreth, Shelby [1 ,3 ]
Gaba, Amit [1 ]
Hlasny, Magda [1 ]
Liu, Guanqun [1 ,3 ]
Huang, Yanyun [4 ]
Zhou, Yan [1 ,2 ,3 ]
机构
[1] Univ Saskatchewan, Vaccine & Infect Dis Org, Int Vaccine Ctr VIDO InterVac, Saskatoon, SK S7N 5E3, Canada
[2] Univ Saskatchewan, Dept Vet Microbiol, Western Coll Vet Med, Saskatoon, SK S7N 5B4, Canada
[3] Univ Saskatchewan, Sch Publ Hlth, Vaccinol & Immunotherapeut Program, Saskatoon, SK S7N 2Z4, Canada
[4] Prairie Diagnost Serv Inc, Saskatoon, SK S7N 5B4, Canada
来源
VIRUSES-BASEL | 2019年 / 11卷 / 02期
关键词
influenza A virus; H5N1; H7N9; pathogenesis in mice; RIG-I; INFECTION; RESPONSES; INDUCTION; CYTOKINE; EFFICACY; ARTICLE; VACCINE;
D O I
10.3390/v11020193
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H7N9 viruses pose a severe threat to public health through zoonotic infection, causing severe respiratory disease in humans. While HPAI H5N1 human infections have typically been reported in Asian countries, avian H7N9 human infections have been reported mainly in China. However, Canada reported a case of fatal human infection by the HPAI H5N1 virus in 2014, and two cases of human illness associated with avian H7N9 virus infection in 2015. While the genomes of the causative viruses A/Alberta/01/2014 (H5N1) (AB14 (H5N1)) and A/British Columbia/1/2015 (H7N9) (BC15 (H7N9)) are reported, the isolates had not been evaluated for their pathogenicity in animal models. In this study, we characterized the pathogenicity of AB14 (H5N1) and BC15 (H7N9) and found that both strain isolates are highly lethal in mice. AB14 (H5N1) caused systemic viral infection and erratic proinflammatory cytokine gene expression in different organs. In contrast, BC15 (H7N9) replicated efficiently only in the respiratory tract, and was a potent inducer for proinflammatory cytokine genes in the lungs. Our study provides experimental evidence to complement the specific human case reports and animal models for evaluating vaccine and antiviral candidates against potential influenza pandemics.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Update on avian influenza A(H5N1) and A(H7N9)
    Kaye, Donald
    CLINICAL INFECTIOUS DISEASES, 2017, 64 (07) : I - I
  • [2] Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses
    Sha, Jianping
    Dong, Wei
    Liu, Shelan
    Chen, Xiaowen
    Zhao, Na
    Luo, Mengyun
    Dong, Yuanyuan
    Zhang, Zhiruo
    PLOS ONE, 2016, 11 (10):
  • [3] Characterization of pseudoparticles paired with hemagglutinin and neuraminidase from highly pathogenic H5N1 influenza and avian influenza A (H7N9) viruses
    Zhang, Fengwei
    Wang, Shanshan
    Wang, Yanan
    Shang, Xuechai
    Zhou, Hongjuan
    Cai, Long
    VIRUS RESEARCH, 2018, 253 : 20 - 27
  • [4] Biosensing methods for the detection of highly pathogenic avian influenza H5N1 and H7N9 viruses
    Li, Zhanming
    Fu, Yingchun
    Liao, Ming
    Li, Yanbin
    ANALYTICAL METHODS, 2017, 9 (36) : 5238 - 5248
  • [5] Differences in the Epidemiology of Human Cases of Avian Influenza A(H7N9) and A(H5N1) Viruses Infection
    Qin, Ying
    Horby, Peter W.
    Tsang, Tim K.
    Chen, Enfu
    Gao, Lidong
    Ou, Jianming
    Tran Hien Nguyen
    Tran Nhu Duong
    Gasimov, Viktor
    Feng, Luzhao
    Wu, Peng
    Jiang, Hui
    Ren, Xiang
    Peng, Zhibin
    Li, Sa
    Li, Ming
    Zheng, Jiandong
    Liu, Shelan
    Hu, Shixiong
    Hong, Rongtao
    Farrar, Jeremy J.
    Leung, Gabriel M.
    Gao, George F.
    Cowling, Benjamin J.
    Yu, Hongjie
    CLINICAL INFECTIOUS DISEASES, 2015, 61 (04) : 563 - 571
  • [6] Global alert to avian influenza virus infection: From H5N1 to H7N9
    Poovorawan, Yong
    Pyungporn, Sunchai
    Prachayangprecha, Slinporn
    Makkoch, Jarika
    PATHOGENS AND GLOBAL HEALTH, 2013, 107 (05) : 217 - 223
  • [7] Characterization of H7N9 avian influenza viruses isolated from duck meat products
    Wu, Li
    Mitake, Hiromichi
    Kiso, Maki
    Ito, Mutsumi
    Iwatsuki-Hirimoto, Kiyoko
    Yamayoshi, Seiya
    Lopes, Tiago J. S.
    Feng, Huapeng
    Sumiyoshi, Riho
    Shibata, Akihiro
    Osaka, Hiroyuki
    Imai, Masaki
    Watanabe, Tokiko
    Kawaoka, Yoshihiro
    TRANSBOUNDARY AND EMERGING DISEASES, 2020, 67 (02) : 792 - 798
  • [8] Characterization of H7N9 influenza A viruses isolated from humans
    Watanabe, Tokiko
    Kiso, Maki
    Fukuyama, Satoshi
    Nakajima, Noriko
    Imai, Masaki
    Yamada, Shinya
    Murakami, Shin
    Yamayoshi, Seiya
    Iwatsuki-Horimoto, Kiyoko
    Sakoda, Yoshihiro
    Takashita, Emi
    McBride, Ryan
    Noda, Takeshi
    Hatta, Masato
    Imai, Hirotaka
    Zhao, Dongming
    Kishida, Noriko
    Shirakura, Masayuki
    de Vries, Robert P.
    Shichinohe, Shintaro
    Okamatsu, Masatoshi
    Tamura, Tomokazu
    Tomita, Yuriko
    Fujimoto, Naomi
    Goto, Kazue
    Katsura, Hiroaki
    Kawakami, Eiryo
    Ishikawa, Izumi
    Watanabe, Shinji
    Ito, Mutsumi
    Sakai-Tagawa, Yuko
    Sugita, Yukihiko
    Uraki, Ryuta
    Yamaji, Reina
    Eisfeld, Amie J.
    Zhong, Gongxun
    Fan, Shufang
    Ping, Jihui
    Maher, Eileen A.
    Hanson, Anthony
    Uchida, Yuko
    Saito, Takehiko
    Ozawa, Makoto
    Neumann, Gabriele
    Kida, Hiroshi
    Odagiri, Takato
    Paulson, James C.
    Hasegawa, Hideki
    Tashiro, Masato
    Kawaoka, Yoshihiro
    NATURE, 2013, 501 (7468) : 551 - +
  • [9] Characterization of H7N9 influenza A viruses isolated from humans
    Tokiko Watanabe
    Maki Kiso
    Satoshi Fukuyama
    Noriko Nakajima
    Masaki Imai
    Shinya Yamada
    Shin Murakami
    Seiya Yamayoshi
    Kiyoko Iwatsuki-Horimoto
    Yoshihiro Sakoda
    Emi Takashita
    Ryan McBride
    Takeshi Noda
    Masato Hatta
    Hirotaka Imai
    Dongming Zhao
    Noriko Kishida
    Masayuki Shirakura
    Robert P. de Vries
    Shintaro Shichinohe
    Masatoshi Okamatsu
    Tomokazu Tamura
    Yuriko Tomita
    Naomi Fujimoto
    Kazue Goto
    Hiroaki Katsura
    Eiryo Kawakami
    Izumi Ishikawa
    Shinji Watanabe
    Mutsumi Ito
    Yuko Sakai-Tagawa
    Yukihiko Sugita
    Ryuta Uraki
    Reina Yamaji
    Amie J. Eisfeld
    Gongxun Zhong
    Shufang Fan
    Jihui Ping
    Eileen A. Maher
    Anthony Hanson
    Yuko Uchida
    Takehiko Saito
    Makoto Ozawa
    Gabriele Neumann
    Hiroshi Kida
    Takato Odagiri
    James C. Paulson
    Hideki Hasegawa
    Masato Tashiro
    Yoshihiro Kawaoka
    Nature, 2013, 501 : 551 - 555
  • [10] Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice
    Murray, Jackelyn
    Martin, David E.
    Hosking, Sarah
    Orr-Burks, Nichole
    Hogan, Robert J.
    Tripp, Ralph A.
    VIRUSES-BASEL, 2024, 16 (01):