Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review

被引：62
|
作者：
O'Dell, Casey M. [1 ]
Das, Arabinda [1 ]
Wallace, Gerald [1 ]
Ray, Swapan K. [2 ]
Banik, Naren L. [1 ]
机构：
[1] Med Univ S Carolina, Div Neurol, Dept Neurosci, Charleston, SC 29425 USA
[2] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC USA
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2012年 / 90卷 / 05期
关键词：
temporal lobe epilepsy; calpain; epileptogenesis; cytokines; ANTIEPILEPTIC DRUG DEVELOPMENT; POSTTRAUMATIC EPILEPSY; STATUS EPILEPTICUS; PILOCARPINE MODEL; ADENOSINE KINASE; BRAIN-INJURY; HIPPOCAMPUS; EPILEPTOGENESIS; CHANNELS; INFLAMMATION;
D O I：
10.1002/jnr.22829
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Despite years of research, epilepsy remains a poorly understood disorder. In the past several years, work has been conducted on a variety of projects with the goal of better understanding the pathogenesis and progression of mesial temporal lobe epilepsy (MTLE), in particular, and how to exploit those properties to generate innovative therapies for treatment of refractory epilepsies. This review seeks to give an overview of common morphological and biochemical changes associated with epilepsy and proposed treatments to address those changes. Furthering the understanding of ictogenesis and epileptogenesis remains an important goal for scientists seeking to find more effective treatments for MTLE. (C) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：913 / 924
页数：12
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