Platelet dysfunction and increased bleeding tendency in McCune-Albright syndrome

被引:13
作者
Bajpai, Anurag [1 ]
Greenway, Anthea [2 ]
Zacharin, Margaret [1 ]
机构
[1] Royal Childrens Hosp, Dept Endocrinol & Diabet, Melbourne, Vic 3052, Australia
[2] Royal Childrens Hosp, Dept Haematol, Melbourne, Vic 3052, Australia
关键词
D O I
10.1016/j.jpeds.2008.02.045
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We observed increased bleeding tendency and platelet function abnormalities in 3 boys with McCune-Albright syndrome (MAS). We speculate that platelet dysfunction contributed to excessive blood loss in our patients. This report of platelet dysfunction in MAS highlights the need for assessment of platelet functions in the condition.
引用
收藏
页码:287 / 289
页数:3
相关论文
共 10 条
[1]  
Chan B, 2006, J PEDIATR ENDOCR MET, V19, P75
[2]  
FAULL CM, 1991, Q J MED, V78, P251
[3]   Clinical application of the PFA-100® [J].
Favaloro, EJ .
CURRENT OPINION IN HEMATOLOGY, 2002, 9 (05) :407-415
[4]   Functional polymorphisms in the paternally expressed XLαs and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation [J].
Freson, K ;
Jaeken, J ;
Van Helvoirt, M ;
de Zegher, F ;
Wittevrongel, C ;
Thys, C ;
Hoylaerts, MF ;
Vermylen, J ;
Van Geet, C .
HUMAN MOLECULAR GENETICS, 2003, 12 (10) :1121-1130
[5]   Pseudo hypoparathyroidism type Ib with disturbed imprinting in the GNAS1 cluster and Gsα deficiency in platelets [J].
Freson, K ;
Thys, C ;
Wittevrongel, C ;
Proesmans, W ;
Hoylaerts, MF ;
Vermylen, J ;
Van Geet, C .
HUMAN MOLECULAR GENETICS, 2002, 11 (22) :2741-2750
[6]   Genetic variation of the extra-large stimulatory G protein α-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding [J].
Freson, K ;
Hoylaerts, MF ;
Jaeken, J ;
Eyssen, M ;
Arnout, J ;
Vermylen, J ;
Van Geet, C .
THROMBOSIS AND HAEMOSTASIS, 2001, 86 (03) :733-738
[7]   The P2 receptors in platelet function [J].
Hechler, B ;
Cattaneo, M ;
Gachet, C .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2005, 31 (02) :150-161
[8]  
Ippolito E, 2002, J PEDIATR ENDOCR MET, V15, P939
[9]   ACTIVATING MUTATIONS OF THE STIMULATORY G-PROTEIN IN THE MCCUNE-ALBRIGHT SYNDROME [J].
WEINSTEIN, LS ;
SHENKER, A ;
GEJMAN, PV ;
MERINO, MJ ;
FRIEDMAN, E ;
SPIEGEL, AM .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (24) :1688-1695
[10]  
Zacharin Margaret, 2007, Pediatr Endocrinol Rev, V4 Suppl 4, P412