A convenient one-pot synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones

被引：4

作者：

Mendez, Leticia J. ^{[1
]}

Canepa, Alicia S. ^{[1
]}

Gloria Gonzalez, M. ^{[2
]}

Bravo, Rodolfo D. ^{[1
]}

机构：

[1] Univ Nacl La Plata, Lab Estudio Compuestos Organ, Dept Quim, Fac Ciencias Exactas, RA-1900 La Plata, Argentina

[2] Natl Univ La Plata, Fac Ciencias Exactas, CINDECA CONICET UNLP, RA-1900 La Plata, Argentina

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 06期

关键词：

1-Aryl-substituted; 2H-isoquinolin-3-ones; One-pot synthesis; Sulfated zirconia; 2-Acylphenylacetonitriles; Intramolecular cyclization; SULFATED ZIRCONIA; EFFICIENT CATALYST;

D O I：

10.1016/j.tetlet.2011.11.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones is studied from 2-cyanomethylbenzoic acid and substituted benzenes via Friedel-Crafts acylation and intramolecular cyclization of 2-acylphenyl-acetonitriles formed in a one-pot method using sulfated zirconia as catalysts. Short reaction times, simplicity of operation, and easy work-up are some advantages of this method. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：688 / 690

页数：3

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