A convenient one-pot synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones

被引：4
|
作者：
Mendez, Leticia J. [1 ]
Canepa, Alicia S. [1 ]
Gloria Gonzalez, M. [2 ]
Bravo, Rodolfo D. [1 ]
机构：
[1] Univ Nacl La Plata, Lab Estudio Compuestos Organ, Dept Quim, Fac Ciencias Exactas, RA-1900 La Plata, Argentina
[2] Natl Univ La Plata, Fac Ciencias Exactas, CINDECA CONICET UNLP, RA-1900 La Plata, Argentina
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 06期
关键词：
1-Aryl-substituted; 2H-isoquinolin-3-ones; One-pot synthesis; Sulfated zirconia; 2-Acylphenylacetonitriles; Intramolecular cyclization; SULFATED ZIRCONIA; EFFICIENT CATALYST;
D O I：
10.1016/j.tetlet.2011.11.128
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones is studied from 2-cyanomethylbenzoic acid and substituted benzenes via Friedel-Crafts acylation and intramolecular cyclization of 2-acylphenyl-acetonitriles formed in a one-pot method using sulfated zirconia as catalysts. Short reaction times, simplicity of operation, and easy work-up are some advantages of this method. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：688 / 690
页数：3
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