Facile Synthesis of Novel Isoflavone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents

被引：4

作者：

Yerrabelly, J. Rao ^{[1
]}

Mallepaka, Pradeep ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500004, Telangana, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 05期

关键词：

7-proporgyloxy isoflavones; dipolarcycloaddition; click chemistry; isoflavone-1; 2; 3-triazole; antimicrobial activity; ONE-POT SYNTHESIS; ISOFLAVONES;

D O I：

10.1134/S1070363220050266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of new hybrid derivatives of isoflavone-1,2,3-triazole conjugated heterocycles has been synthesized from 7-hydroxy isoflavone by Cu(I) catalysed azidoalkyne [3+2]cycloaddition. The synthesized compounds have been tested for anti-bacterial activity against gram positiveBacillus subtilis,gram negativeEscherichia coliand anti-fungal activity againstSclerotium Rolfsii, Macrophomina phaseolina.Three products demonstrate moderate activity againstBacillus subtilisand three compounds are characterized as highly anti-fungal agents forSclerotium Rolfsii.

引用

页码：911 / 916

页数：6

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