CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia

被引:24
作者
Barragan, Eva [1 ,2 ]
Chillon, Maria Carmen [3 ]
Castello-Cros, Remedios [4 ]
Marcotegui, Nerea [4 ]
Prieto, Maria Isabel [3 ]
Hoyos, Montserrat [5 ]
Pippa, Raffaella [4 ]
Llop, Marta [1 ,2 ]
Etxabe, Amaia [4 ]
Cervera, Jose [1 ,2 ]
Rodriguez, Gabriela [6 ]
Buno, Ismael [6 ]
Rifon, Jose [7 ]
Sierra, Jorge [5 ]
Gonzalez, Marcos [3 ]
Calasanz, Maria J. [8 ]
Sanz, Miguel A. [1 ,2 ]
Odero, Maria D. [4 ,8 ]
机构
[1] Univ Hosp La Fe, Clin Lab, Valencia, Spain
[2] Univ Hosp La Fe, Dept Hematol, Valencia, Spain
[3] Univ Hosp Salamanca, Salamanca Inst Biomed Res IBSAL, Salamanca, Spain
[4] Univ Navarra, CIMA, Program Hematol Oncol, E-31080 Pamplona, Spain
[5] Hosp Santa Creu & Sant Pau, Dept Hematol, E-08025 Barcelona, Spain
[6] Gregorio Maranon Inst Hlth Res, Dept Hematol, Madrid, Spain
[7] Univ Navarra Clin, Dept Hematol, Pamplona, Spain
[8] Univ Navarra, Dept Biochem & Genet, E-31080 Pamplona, Spain
关键词
acute myeloid leukemia; normal karyotype; CIP2; prognosis; overall survival; PROTEIN PHOSPHATASE 2A; SET; MUTATIONS; THERAPY; TARGET; EVENT; CELLS;
D O I
10.3324/haematol.2014.118117
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
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页数:3
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共 14 条
[1]   Antagonism of SET Using OP449 Enhances the Efficacy of Tyrosine Kinase Inhibitors and Overcomes Drug Resistance in Myeloid Leukemia [J].
Agarwal, Anupriya ;
MacKenzie, Ryan J. ;
Pippa, Raffaella ;
Eide, Christopher A. ;
Oddo, Jessica ;
Tyner, Jeffrey W. ;
Sears, Rosalie ;
Vitek, Michael P. ;
Odero, Maria D. ;
Christensen, Dale J. ;
Druker, Brian J. .
CLINICAL CANCER RESEARCH, 2014, 20 (08) :2092-2103
[2]   Treatment of acute myeloid leukemia: are we making progress? [J].
Burnett, Alan K. .
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2012, :1-6
[3]   CIP2A Is Associated with Human Breast Cancer Aggressivity [J].
Come, Christophe ;
Laine, Anni ;
Chanrion, Maia ;
Edgren, Henrik ;
Mattila, Elina ;
Liu, Xiaoling ;
Jonkers, Jos ;
Ivaska, Johanna ;
Isola, Jorma ;
Darbon, Jean-Marie ;
Kallioniemi, Olli ;
Thezenas, Simon ;
Westermarck, Jukka .
CLINICAL CANCER RESEARCH, 2009, 15 (16) :5092-5100
[4]   PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect [J].
Cristobal, I. ;
Garcia-Orti, L. ;
Cirauqui, C. ;
Alonso, M. M. ;
Calasanz, M. J. ;
Odero, M. D. .
LEUKEMIA, 2011, 25 (04) :606-614
[5]   Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia [J].
Cristobal, Ion ;
Garcia-Orti, Laura ;
Cirauqui, Cristina ;
Cortes-Lavaud, Xabier ;
Garcia-Sanchez, Maria A. ;
Calasanz, Maria J. ;
Odero, Maria D. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (04) :543-550
[6]   Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target [J].
Khanna, Anchit ;
Pimanda, John E. ;
Westermarck, Jukka .
CANCER RESEARCH, 2013, 73 (22) :6548-6553
[7]   Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1 [J].
Laine, Anni ;
Sihto, Harri ;
Come, Christophe ;
Rosenfeldt, Mathias T. ;
Zwolinska, Aleksandra ;
Niemela, Minna ;
Khanna, Anchit ;
Chan, Edward K. ;
Kahari, Veli-Matti ;
Kellokumpu-Lehtinen, Pirkko-Liisa ;
Sansom, Owen J. ;
Evan, Gerard I. ;
Junttila, Melissa R. ;
Ryan, Kevin M. ;
Marine, Jean-Christophe ;
Joensuu, Heikki ;
Westermarck, Jukka .
CANCER DISCOVERY, 2013, 3 (02) :182-197
[8]   c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations [J].
Luo, H ;
Li, C ;
O'Neal, J ;
Kreisel, F ;
Le Beau, MM ;
Tomasson, MH .
BLOOD, 2005, 106 (07) :2452-2461
[9]   Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications [J].
Marcucci, Guido ;
Haferlach, Torsten ;
Doehner, Hartmut .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (05) :475-486
[10]   How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia? [J].
Patel, Jay P. ;
Levine, Ross L. .
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2012, :28-34